N-Methoxy-N,2,2-trimethylpropanamide
- Product Name
- N-Methoxy-N,2,2-trimethylpropanamide
- CAS No.
- 64214-60-4
- Chemical Name
- N-Methoxy-N,2,2-trimethylpropanamide
- Synonyms
- N-Methoxy-N,2,2-trimethylpropanamide;Propanamide, N-methoxy-N,2,2-trimethyl-
- CBNumber
- CB42565293
- Molecular Formula
- C7H15NO2
- Formula Weight
- 145.2
- MOL File
- 64214-60-4.mol
N-Methoxy-N,2,2-trimethylpropanamide Property
- Boiling point:
- 62-64 °C(Press: 10 Torr)
- Density
- 0.937±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2928009090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M268780
- Product name
- N-Methoxy-N,2,2-trimethylpropanamide
- Packaging
- 1g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 9831AB
- Product name
- N-Methoxy-N-methylpivalamide
- Packaging
- 5g
- Price
- $411
- Updated
- 2021/12/16
- Product number
- 188534
- Product name
- N-Methoxy-N-methylpivalamide
- Packaging
- 5g
- Price
- $478
- Updated
- 2021/12/16
- Product number
- 188534
- Product name
- N-Methoxy-N-methylpivalamide
- Packaging
- 10g
- Price
- $833
- Updated
- 2021/12/16
- Product number
- 188534
- Product name
- N-Methoxy-N-methylpivalamide
- Packaging
- 25g
- Price
- $1666
- Updated
- 2021/12/16
N-Methoxy-N,2,2-trimethylpropanamide Chemical Properties,Usage,Production
Synthesis
1117-97-1
75-98-9
64214-60-4
GENERAL PROCEDURE: Methoxymethylamine (0.360 g, 6.0 mmol) and valproic acid (0.244 g, 2.0 mmol) were dissolved in anhydrous toluene (10 mL) and stirred for 10 min at 0 °C. Subsequently, a solution of phosphorus trichloride (0.137 g, 1.0 mmol) in anhydrous toluene (2 mL) was slowly added dropwise to the reaction mixture. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature and stirring was continued for 0.5 h at 60 °C. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the mixture was cooled to room temperature. The reaction was quenched with saturated sodium bicarbonate solution (20 mL) and subsequently extracted with ethyl acetate (3 x 10 mL). The organic phases were combined and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by column chromatography (silica gel, petroleum ether-ethyl acetate, 3:2) to afford N-methoxy-N,2,2-trimethylpropionamide (3a) as a colorless oil. Yield: 320 mg (97%).
References
[1] Synthesis (Germany), 2014, vol. 46, # 3, p. 320 - 330
[2] Journal of Organic Chemistry, 2004, vol. 69, # 25, p. 8984 - 8986
N-Methoxy-N,2,2-trimethylpropanamide Preparation Products And Raw materials
Raw materials
Preparation Products
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