NQDI 1

Product Name: NQDI 1
CAS No.: 175026-96-7
Chemical Name: NQDI 1
Synonyms: NQDI 1;NDQI 1;CS-1567;NQDI-1（97%）;NQDI-1, >98%;NQDI-1 ，S8289;NQDI-1 (NQDI 1);NQDI-1, ≥98% (HPLC);NQDI-1;NQDI 1;NQDI1;NQDI-1, 10 mM in DMSO
CBNumber: CB42574688
Molecular Formula: C19H13NO4
Formula Weight: 319.31
MOL File: 175026-96-7.mol

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NQDI 1 Property

Melting point:: 310 °C (decomp)
Boiling point:: 581.4±50.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥5mg/mL (warmed to 60° C)
form: powder
pka: 10.76±0.40(Predicted)
color: orange
Stability:: Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Safety

WGK Germany: 3
HS Code: 2933790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16226
Product name: NQDI-1
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16226
Product name: NQDI-1
Purity: ≥95%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 16226
Product name: NQDI-1
Purity: ≥95%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 16226
Product name: NQDI-1
Purity: ≥95%
Packaging: 25mg
Price: $381
Updated: 2024/03/01

Tocris

Product number: 4429
Product name: NQDI1
Purity: ≥99%(HPLC)
Packaging: 10
Price: $221
Updated: 2021/12/16

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NQDI 1 Chemical Properties,Usage,Production

Description

Apoptosis signal-regulating kinase 1 (ASK1) is the ubiquitously expressed mitogen-activated protein kinase kinase kinase 5 involved in a wide range of biological functions that are dependent on cell survival or death. NQDI-1 is a specific inhibitor of ASK1 (IC₅₀ = 3 μM; K_i = 500 nM) that demonstrates potent selectivity against various serine/threonine and tyrosine protein kinases. It has been used to promote survival of induced pluripotent stem cell populations and to protect neurons from reactive oxygen species-induced apoptosis in a model of ischemia.

Uses

NQDI-1 is an ASK1 inhibitor which is of therapeutic potential against acute ischemic renal injury. ?Its protective effects are mediated through inhibition of apoptosis and oxidative stress.

in vivo

250 nmol NQDI-1 in DMSO is intracerebroventricularly injected following brain insult. Western blotting is performed to determine the expression of ASK1 in the sham, Hypoxia-ischemia (HI), DMSO and NQDI-1 groups and indicate that NQDI-1 markedly inhibits the expression of ASK1 in the brain cortex, compared with the HI and DMSO group. Furthermore, immunofluorescence staining also indicates that the expression of ASK1 is inhibited by NQDI-1 in the brain cortex. The expression of downstream targets of ASK1 is also determined in the present study. The expression levels of p-JNK, p-c-Jun, p53 and caspase 3 are significantly decreased by NQDI-1, compared with the HI and DMSO groups. Low expression of p-JNK in the brain cortex is also observed by immunofluorescence in the NQDI-1-treated group^[2].

IC 50

ASK1: 500 nM (Ki); ASK1: 3 μM (IC₅₀)

References

[1] GALYNA P. VOLYNETS. Identification of 3H-Naphtho[1,2,3-de]quinoline-2,7-diones as Inhibitors of Apoptosis Signal-Regulating Kinase 1 (ASK1)[J]. Journal of Medicinal Chemistry, 2011, 54 8: 2680-2686. DOI:10.1021/jm200117h
[2] KOJI NOMURA . An ASK1-p38 signalling pathway mediates hydrogen peroxide-induced toxicity in NG108-15 neuronal cells[J]. Neuroscience Letters, 2013, 549: Pages 163-167. DOI:10.1016/j.neulet.2013.05.045
[3] SHENGPAN CHEN. The MC4 receptor agonist RO27-3225 inhibits NLRP1-dependent neuronal pyroptosis via the ASK1/JNK/p38 MAPK pathway in a mouse model of intracerebral haemorrhage[J]. British Journal of Pharmacology, 2019, 176 9: 1341-1356. DOI:10.1111/bph.14639
[4] LIWEI MA. Low glucose and metformin-induced apoptosis of human ovarian cancer cells is connected to ASK1 via mitochondrial and endoplasmic reticulum stress-associated pathways.[J]. Journal of Experimental & Clinical Cancer Research, 2019: 77. DOI:10.1186/s13046-019-1090-6
[5] HAO FENG. Dual function of peroxiredoxin I in lipopolysaccharide-induced osteoblast apoptosis via reactive oxygen species and the apoptosis signal-regulating kinase 1 signaling pathway.[J]. Cell Death Discovery, 2018: 47. DOI:10.1038/s41420-018-0050-9

NQDI 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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NQDI 1 Suppliers

China 110 India 2 United Kingdom 1 United States 15 Global 128

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View Lastest Price from NQDI 1 manufacturers

Career Henan Chemical Co

Product: NQDI 1 175026-96-7
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

175026-96-7, NQDI 1Related Search:

BI 2536 Acalabrutinib DO264 Elafibranor(GFT505)

LESINURAD (RDEA-594) intermediate

2,7-Dihydro-2,7-dioxo-3H-naphtho[1,2,3-de]quinoline-1-carboxylic acid ethyl ester

NDQI 1

NQDI 1

3H-Naphtho[1,2,3-de]quinoline-1-carboxylic acid, 2,7-dihydro-2,7-dioxo-, ethyl ester

CS-1567

NQDI-1（97%）

NQDI-1;NQDI 1;NQDI1

NQDI-1, >98%

NQDI-1, ≥98% (HPLC)

Ethyl 2,7-dihydro-2,7-dioxo-3H-naphtho[1,2,3-de]quinoline-1-carboxylate

inhibit,Apoptosis,NQDI-1,Inhibitor,MAP kinase kinase kinase, MEKK, MAPKKK,MAP3K

1-ethyl-anthra<1,9-bc>pyridine-2,7-dione-carboxylate

NQDI-1, 10 mM in DMSO

NQDI-1 (NQDI 1)

NQDI-1 ，S8289

Ethyl 2,7-dihydro-2,7-dioxo-3H-naphtho[1,2,3-de]quinoline-1-carboxylate - [AC80445]

175026-96-7

75026-96-7