2,5-Dichloroquinoline
Uses- Product Name
- 2,5-Dichloroquinoline
- CAS No.
- 59412-12-3
- Chemical Name
- 2,5-Dichloroquinoline
- Synonyms
- 2,5-DICHLOROQUINOLINE;DICHLOROQUINOLINE(2,5-);Quinoline, 2,5-dichloro-;2,5-Dichloroquinoline,95%,QC-6736
- CBNumber
- CB4257989
- Molecular Formula
- C9H5Cl2N
- Formula Weight
- 198.05
- MOL File
- 59412-12-3.mol
2,5-Dichloroquinoline Property
- Melting point:
- 76-77 °C(Solv: hexane (110-54-3))
- Boiling point:
- 304.0±22.0 °C(Predicted)
- Density
- 1.407±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.77±0.50(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D482505
- Product name
- 2,5-dichloroquinoline
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- OR917331
- Product name
- 2,5-Dichloroquinoline
- Purity
- 95%
- Packaging
- 250mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- 3H32-5-E9
- Product name
- 2,5-Dichloroquinoline
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- 8844AB
- Product name
- 2,5-Dichloroquinoline
- Packaging
- 1g
- Price
- $226
- Updated
- 2021/12/16
- Product number
- 3H32-5-E9
- Product name
- 2,5-Dichloroquinoline
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $490
- Updated
- 2021/12/16
2,5-Dichloroquinoline Chemical Properties,Usage,Production
Uses
2,5-Dichloroquinoline can be used as a pharmaceutical synthesis intermediate.
Synthesis
90224-97-8
59412-12-3
Step 2: Preparation of 5-chloro-2-chloroquinoline (compound 181-3) To a solution of 5-chloroquinoline azide (compound 181-2, 19 g, 106 mmol) in dichloromethane (DCM, 250 mL) was added phosphorus oxychloride (POCl3, 32 g, 212 mmol). The reaction mixture was heated to 40°C and stirred for 1.5 hours. Upon completion of the reaction, saturated aqueous sodium bicarbonate (NaHCO3) solution (500 mL) was slowly added and the mixture was stirred at 15°C for 10 minutes. Subsequently, the aqueous phase was extracted with ethyl acetate (300 mL x 3). The organic phases were combined, washed with brine (500 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated in vacuum. The residue was purified by column chromatography (silica gel 100-200 mesh, column height: 250 mm, diameter: 100 mm, eluent: petroleum ether/ethyl acetate=50/1~20/1) to afford 5-chloro-2-chloroquinoline (Compound 181-3, 9.8 g, 40% yield) as a white solid.
References
[1] Patent: WO2016/54491, 2016, A1. Location in patent: Paragraph 00625
[2] Bioorganic and medicinal chemistry, 2002, vol. 10, # 8, p. 2611 - 2623
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 5, p. 1472 - 1476
2,5-Dichloroquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
2,5-Dichloroquinoline Suppliers
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View Lastest Price from 2,5-Dichloroquinoline manufacturers
- Product
- DICHLOROQUINOLINE(2,5-) 59412-12-3
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-04-24
- Product
- 2,5-Dichloroquinoline 59412-12-3
- Price
- US $1.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%+
- Supply Ability
- 100 tons
- Release date
- 2019-12-26
- Product
- 2,5-Dichloroquinoline 59412-12-3
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2020-01-15