7(R)-Maresin 1

Product Name: 7(R)-Maresin 1
CAS No.: 1268720-28-0
Chemical Name: 7(R)-Maresin 1
Synonyms: Maresin 1;7(R)-Maresin 1;Lactic acid impurity 102;HLHYXXBCQOUTGK-FHCQLJOMSA-N;7(R)-Maresin 1 Exclusive;Maresin 1(solution in ethanol);4,8,10,12,16,19-Docosahexaenoic acid, 7,14-dihydroxy-, (4Z,7R,8E,10E,12Z,14S,16Z,19Z)-
CBNumber: CB42590080
Molecular Formula: C22H32O4
Formula Weight: 360.49
MOL File: 1268720-28-0.mol

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7(R)-Maresin 1 Property

Boiling point:: 559.4±50.0 °C(Predicted)
Density: 1.048±0.06 g/cm3(Predicted)
storage temp.: Store at -80°C, protect from light
solubility: DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.05 mg/ml
form: Liquid
pka: 4.58±0.10(Predicted)
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10878
Product name: Maresin 1
Purity: ≥95%
Packaging: 10μg
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 10878
Product name: Maresin 1
Purity: ≥95%
Packaging: 25μg
Price: $180
Updated: 2024/03/01

Cayman Chemical

Product number: 10878
Product name: Maresin 1
Purity: ≥95%
Packaging: 50μg
Price: $340
Updated: 2024/03/01

Cayman Chemical

Product number: 10878
Product name: Maresin 1
Purity: ≥95%
Packaging: 100μg
Price: $602
Updated: 2024/03/01

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7(R)-Maresin 1 Chemical Properties,Usage,Production

Uses

Maresin 1-d5 is the deuterium labeled Maresin 1. Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3].

Definition

ChEBI: (7R,14S)-dihydroxy-(4Z,8E,10E,12Z,16Z,19Z)-docosahexaenoic acid is a dihydroxydocosahexaenoic acid that is (4Z,8E,10E,12Z,16Z,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at the 7R- and 14S-positions. It has a role as an anti-inflammatory agent, a human xenobiotic metabolite, a hepatoprotective agent and a specialised pro-resolving mediator. It is a dihydroxydocosahexaenoic acid and a secondary allylic alcohol. It is functionally related to an all-cis-docosa-4,7,10,13,16,19-hexaenoic acid.

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Markus V Olsen, et al. Maresin 1, a Specialized Proresolving Mediator, Stimulates Intracellular [Ca 2+ ] and Secretion in Conjunctival Goblet Cells. J Cell Physiol. 2020 Jun 8. DOI:10.1002/jcp.29846
[3] Macrophage Proresolving Mediator Maresin 1 Stimulates Tissue Regeneration and Controls Pain DOI:10.1096/fj.11-201442
[4] Rodrigo Marcon, et al. Maresin 1, a Proresolving Lipid Mediator Derived From omega-3 Polyunsaturated Fatty Acids, Exerts Protective Actions in Murine Models of Colitis. J Immunol. 2013 Oct 15;191(8):4288-98. DOI:10.4049/jimmunol.1202743

7(R)-Maresin 1 Preparation Products And Raw materials

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Preparation Products

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7(R)-Maresin 1 Suppliers

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1268720-28-0, 7(R)-Maresin 1Related Search:

7(R)-Maresin 1

Maresin 1

7(R)-Maresin 1 Exclusive

HLHYXXBCQOUTGK-FHCQLJOMSA-N

4,8,10,12,16,19-Docosahexaenoic acid, 7,14-dihydroxy-, (4Z,7R,8E,10E,12Z,14S,16Z,19Z)-

Lactic acid impurity 102

Maresin 1(solution in ethanol)

1268720-28-0