ChemicalBook > CAS DataBase List > CAY10618

CAY10618

Product Name
CAY10618
CAS No.
1202580-59-3
Chemical Name
CAY10618
Synonyms
GPP 78;CAY10618;GPP78,GPP-78;CAY10618 Exclusive;N-(2-phenylphenyl)-8-(4-pyridin-3-yltriazol-1-yl)octanamide;1H-1,2,3-Triazole-1-octanaMide, N-[1,1'-biphenyl]-2-yl-4-(3-pyridinyl)-
CBNumber
CB42590444
Molecular Formula
C27H29N5O
Formula Weight
439.55
MOL File
1202580-59-3.mol
More
Less

CAY10618 Property

Density 
1.15±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 10 mg/ml
pka
14.80±0.70(Predicted)
form 
Liquid
color 
Colorless to light yellow
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
13670
Product name
GPP 78
Purity
≥95%
Packaging
500μg
Price
$20
Updated
2024/03/01
Cayman Chemical
Product number
13670
Product name
GPP 78
Purity
≥95%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
13670
Product name
GPP 78
Purity
≥95%
Packaging
5mg
Price
$146
Updated
2024/03/01
Cayman Chemical
Product number
13670
Product name
GPP 78
Purity
≥95%
Packaging
10mg
Price
$257
Updated
2024/03/01
AK Scientific
Product number
4481DF
Product name
N-(2-Phenylphenyl)-8-[4-(3-pyridinyl)-1-triazolyl]octanamide
Packaging
5mg
Price
$262
Updated
2021/12/16
More
Less

CAY10618 Chemical Properties,Usage,Production

Description

Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD+ by NMN adenyltransferase. Cancer cells commonly have an unusually high rate of NAD+ turnover, suggesting that inhibition of Nampt might selectively target cancer cells. GPP 78 is a potent inhibitor of Nampt (IC50 = 3 nM). It induces cell death in the neuroblastoma cell line SH-SY5Y with an IC50 value of 3.8 nM through a process that appears to involve autophagy.

Uses

GPP78 (CAY10618) is a potent Nampt inhibitor with an IC50 of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC50 of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects[1][2].

Definition

ChEBI: N-(2-phenylphenyl)-8-[4-(3-pyridinyl)-1-triazolyl]octanamide is a member of biphenyls.

in vivo

GPP78 (10 mg/kg; intraperitoneal injection; daily; 1 hour or 6 hours after SCI; for 19 days; male adult CD1 mice) treatment reduces the severity of spinal cord trauma in SCI mice[2].

Animal Model:Male adult CD1 mice (25-30 g) with spinal cord injury (SCI)[2]
Dosage:10 mg/kg
Administration:Intraperitoneal injection; daily; 1 hour or 6 hours after SCI; for 19 days
Result:Significantly reduced the demyelination associated with SCI. And significantly ameliorated the functional deficits induced by SCI.

References

[1] Colombano G, et al. A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J Med Chem. 2010 Jan 28;53(2):616-23. DOI:10.1021/jm9010669
[2] Esposito E, et al. The NAMPT inhibitor FK866 reverts the damage in spinal cord injury. J Neuroinflammation. 2012 Apr 10;9:66. DOI:10.1186/1742-2094-9-66

CAY10618 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CAY10618 Suppliers

China 28 United States 4 Global 32
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
18108052721 18108052721;
Email
2850505130@qq.com
Country
China
ProdList
5088
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24960
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11972
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58

1202580-59-3, CAY10618Related Search:


  • CAY10618
  • 1H-1,2,3-Triazole-1-octanaMide, N-[1,1'-biphenyl]-2-yl-4-(3-pyridinyl)-
  • GPP 78
  • CAY10618 Exclusive
  • N-(2-phenylphenyl)-8-(4-pyridin-3-yltriazol-1-yl)octanamide
  • GPP78,GPP-78
  • 1202580-59-3