GN25
- Product Name
- GN25
- CAS No.
- 1227401-27-5
- Chemical Name
- GN25
- Synonyms
- GN25;DIIRLGMLDOPLPV-UHFFFAOYSA-N;Propanoic acid, 3-[(1,4-dihydro-5,8-dimethoxy-1,4-dioxo-2-naphthalenyl)thio]-
- CBNumber
- CB42591113
- Molecular Formula
- C15H14O6S
- Formula Weight
- 322.33
- MOL File
- 1227401-27-5.mol
GN25 Property
- Boiling point:
- 608.4±55.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤0.25mg/ml in ethanol;5mg/ml in DMSO;10mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 4.24±0.10(Predicted)
- color
- Light yellow to orange
N-Bromosuccinimide Price
- Product number
- 10948
- Product name
- GN25
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 10948
- Product name
- GN25
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $64
- Updated
- 2024/03/01
- Product number
- 10948
- Product name
- GN25
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $150
- Updated
- 2024/03/01
- Product number
- 10948
- Product name
- GN25
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $264
- Updated
- 2024/03/01
- Product number
- C4840
- Product name
- GN25
- Packaging
- 50mg
- Price
- $299
- Updated
- 2021/12/16
GN25 Chemical Properties,Usage,Production
Description
The tumor suppressor gene, p53, is often mutated or suppressed in human cancers. Oncogenic K-Ras has been shown to inhibit p53 function by inducing Snail to bind and eliminate p53 through exocytosis. GN25 is a 2-
Uses
GN25 is a specific p53-Snail binding inhibitor with antitumor effects[1].
in vivo
GN25 (10 and 20 mg/kg; i.p. once a week for 10 weeks) blocks the tumor progression and induces tumor regression in mice[1].
| Animal Model: | Athymic mice with A549 xenografts[1] |
| Dosage: | 10 and 20 mg/kg |
| Administration: | Intraperitoneal injection; once a week for 10 weeks |
| Result: | Obviously regressed tumors in mice. Showed no significant toxicity in liver, pancreas and kidney. |
References
[1]. lee sh, shen gn, jung ys, et al. antitumor effect of novel small chemical inhibitors of snail-p53 binding in k-ras-mutated cancer cells. oncogene. 2010 aug 12;29(32):4576-87.
GN25 Preparation Products And Raw materials
Raw materials
Preparation Products
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