GN25

Product Name: GN25
CAS No.: 1227401-27-5
Chemical Name: GN25
Synonyms: GN25;DIIRLGMLDOPLPV-UHFFFAOYSA-N;Propanoic acid, 3-[(1,4-dihydro-5,8-dimethoxy-1,4-dioxo-2-naphthalenyl)thio]-
CBNumber: CB42591113
Molecular Formula: C15H14O6S
Formula Weight: 322.33
MOL File: 1227401-27-5.mol

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GN25 Property

Boiling point:: 608.4±55.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤0.25mg/ml in ethanol;5mg/ml in DMSO;10mg/ml in dimethyl formamide
form: crystalline solid
pka: 4.24±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10948
Product name: GN25
Purity: ≥98%
Packaging: 5mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 10948
Product name: GN25
Purity: ≥98%
Packaging: 10mg
Price: $64
Updated: 2024/03/01

Cayman Chemical

Product number: 10948
Product name: GN25
Purity: ≥98%
Packaging: 25mg
Price: $150
Updated: 2024/03/01

Cayman Chemical

Product number: 10948
Product name: GN25
Purity: ≥98%
Packaging: 50mg
Price: $264
Updated: 2024/03/01

ApexBio Technology

Product number: C4840
Product name: GN25
Packaging: 50mg
Price: $299
Updated: 2021/12/16

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GN25 Chemical Properties,Usage,Production

Description

The tumor suppressor gene, p53, is often mutated or suppressed in human cancers. Oncogenic K-Ras has been shown to inhibit p53 function by inducing Snail to bind and eliminate p53 through exocytosis. GN25 is a 2-thio-dimethoxy naphthoquinone analog that blocks Snail binding to p53 and induces p53 expression in cancer cells in a K-Ras dependent manner. At 10 μM, GN25 significantly reduces cell proliferation in K-Ras mutated A549 and HCT116 cell lines but not in wild type MKN-45 cells. In a xenograft mouse model, 10 mg/kg GN25 yields antitumoral effects by notably reducing tumor size and progression.

References

[1]. lee sh, shen gn, jung ys, et al. antitumor effect of novel small chemical inhibitors of snail-p53 binding in k-ras-mutated cancer cells. oncogene. 2010 aug 12;29(32):4576-87.

GN25 Preparation Products And Raw materials

Raw materials

Preparation Products

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GN25 Suppliers

China 31 United States 3 Global 34

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52925
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

1227401-27-5, GN25Related Search:

GN25

DIIRLGMLDOPLPV-UHFFFAOYSA-N

Propanoic acid, 3-[(1,4-dihydro-5,8-dimethoxy-1,4-dioxo-2-naphthalenyl)thio]-

1227401-27-5