ChemicalBook > CAS DataBase List > HTS 01037

HTS 01037

Product Name
HTS 01037
CAS No.
682741-29-3
Chemical Name
HTS 01037
Synonyms
HTS 01037;HTS 01037 (HTS01037;4-{[2-(methoxycarbonyl)-5-(2-thinyl)-3-thienyl]amino}-4-oxo-2-butenoic acid;[2,2'-Bithiophene]-5-carboxylic acid, 4-[(3-carboxy-1-oxo-2-propen-1-yl)amino]-, 5-methyl ester
CBNumber
CB42591315
Molecular Formula
C14H11NO5S2
Formula Weight
337.37
MOL File
682741-29-3.mol
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HTS 01037 Property

Boiling point:
621.2±55.0 °C(Predicted)
Density 
1.493±0.06 g/cm3(Predicted)
storage temp. 
RT
solubility 
Soluble in DMSO (up to 50 mg/ml)
pka
3.39±0.10(Predicted)
form 
solid
color 
Yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10699
Product name
HTS 01037
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
10699
Product name
HTS 01037
Purity
≥98%
Packaging
5mg
Price
$70
Updated
2024/03/01
Cayman Chemical
Product number
10699
Product name
HTS 01037
Purity
≥98%
Packaging
10mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
10699
Product name
HTS 01037
Purity
≥98%
Packaging
25mg
Price
$305
Updated
2024/03/01
ChemScene
Product number
CS-6858
Product name
HTS01037
Purity
99.76%
Packaging
25mg
Price
$312
Updated
2021/12/16
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HTS 01037 Chemical Properties,Usage,Production

Description

Adipocyte fatty acid binding protein (A-FABP/aP2) is a carrier protein expressed in both adipocytes and macrophages where it functions in intracellular fatty acid solubilization, trafficking, and metabolism. Molecular disruption of A-FABP/aP2 in mice results in improved insulin sensitivity and protection from atherosclerosis. HTS 01037 is a high-affinity ligand of adipocyte fatty acid binding protein (A-FABP/aP2) (Ki = 0.67 μM) that presumably competes with fatty acids for functional binding in the ligand-binding cavity of A-FABP/aP2. At a concentration of 10 μM, HTS 01037 antagonizes the protein-protein interaction of A-FABP/aP2 with hormone sensitive lipase in cultured C8PA lipocytes. HTS 01037 inhibits lipolysis in 3T3L1 adipocytes and reduces lipopolysaccharide-stimulated inflammation in bone marrow-derived macrophages, both effects of which are similar to the phenotype of A-FABP/aP2 knockout mice.

Uses

HTS 01037 is an inhibitor of fatty acid binding protein and a competitive antagonist of protein-protein interactions mediated by AFABP/aP2.

Definition

ChEBI: HTS 01037 is a ring assembly and a member of thiophenes.

References

1) Hertzel?et al. (2009),?Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins; J. Med. Chem,?52?6024 2) Long?et al. (2012),?Fatty acids induce leukotriene C4 synthesis in macrophages in a fatty acid binding protein-dependent manner;?Biochim. Biophys. Acta,?1831?1199 3) Xu?et al.?(2015),?Uncoupling lipid metabolism from inflammation through fatty acid binding protein-dependent expression of USP2; Mol. Cell. Biol.,?35?1055 4) Steen?et al. (2016),?FABP4/aP2 regulates macrophage redox signaling and inflammasome activation via control of UCP2; Mol. Cell. Biol.,?37 e00282 5) Boss?et al.?(2015),?FABP4 inhibition suppresses PPARgamma activity and VLDL-induced foam cell formation in IL-4-polarized human macrophages; Atherosclerosis,?240?424

HTS 01037 Preparation Products And Raw materials

Raw materials

Preparation Products

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HTS 01037 Suppliers

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682741-29-3, HTS 01037Related Search:

Zileuton Prostaglandin E2 URB597 Palmitoylethanolamide

  • HTS 01037
  • HTS 01037 (HTS01037
  • 4-{[2-(methoxycarbonyl)-5-(2-thinyl)-3-thienyl]amino}-4-oxo-2-butenoic acid
  • [2,2'-Bithiophene]-5-carboxylic acid, 4-[(3-carboxy-1-oxo-2-propen-1-yl)amino]-, 5-methyl ester
  • 682741-29-3