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LH 21

Product Name
LH 21
CAS No.
611207-11-5
Chemical Name
LH 21
Synonyms
LH 21;LH21; LH 21;LH 21 Exclusive;1H-1,2,4-Triazole, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-
CBNumber
CB42591597
Molecular Formula
C20H20Cl3N3
Formula Weight
408.75
MOL File
611207-11-5.mol
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LH 21 Property

storage temp. 
Store at -20°C
solubility 
≤10mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide
form 
crystalline solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13453
Product name
LH 21
Purity
≥98%
Packaging
1mg
Price
$60
Updated
2024/03/01
Cayman Chemical
Product number
13453
Product name
LH 21
Purity
≥98%
Packaging
5mg
Price
$259
Updated
2024/03/01
Cayman Chemical
Product number
13453
Product name
LH 21
Purity
≥98%
Packaging
10mg
Price
$457
Updated
2024/03/01
ApexBio Technology
Product number
C3642
Product name
LH21
Packaging
10mg
Price
$521
Updated
2021/12/16
AK Scientific
Product number
5792CR
Product name
5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1,2,4-triazole
Packaging
10mg
Price
$607
Updated
2021/12/16
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LH 21 Chemical Properties,Usage,Production

Description

LH 21 is a 1,2,4-triazole that acts as a cannabimimetic. It has a relatively low-affinity for the central cannabinoid (CB1) receptor (Ki = 855 nM). However, it interferes, at low nanomolar concentrations, with the action of the potent CB1 agonist WIN 55,212-2 on murine vas deferens, suggesting that LH 21 acts as a silent CB1 antagonist. Consistent with this interpretation, LH 21 diminishes the in vivo effects of WIN 55,212-2 on standard CB tetrad responses in mice and reduces food intake and body weight gain in obese Zucker rats. However, in CHO cells overexpressing CB1, LH 21 is able to elevate cAMP, suggesting that, in this model, it acts as an inverse agonist of CB1. Furthermore, LH 21 suppresses food intake and body weight gain in both wild-type and CB1 receptor knockout mice, indicating that this receptor is not necessary for these effects.

in vitro

previous study showed that lh-21 was able to inhibit the binding of [3h]cp55940 to cloned human and rat cb1 receptors with ic50 values of 631 ±98 nm, and 690 ± 41 nm, respectively. lh-21 acted as an inverse agonist in a camp functional assay using cultured cells expressing human, rat or mouse cb1 receptor. in addition, in cho cells overexpressing cb1, lh-21 was able to elevate camp, further confirming that lh-21 acted as an inverse agonist of cb1 in this model [1].

in vivo

animal study showed that when given acutely lh-21 could decrease food intake and enhance the anorectic actions of oleoylethanolamide, a feeding suppressant lipid acting on peripheral sensory terminals in a similar way as rimonabant. however, unlike rimonabant, chronic administration of lh-21 at 3 mg/kg was able to reduce feeding but did not improve hypercholesterolaemia or hypertriglyceridaemia; nor did it reduce liver fat deposits in zucker rats [2].

IC 50

631 ±98 and 690 ± 41 nm for human and rat cb1 receptors, respectively

References

[1] chen, r. z.,frassetto, a.,lao, j.z., et al. pharmacological evaluation of lh-12, a newly discovered molecule that binds to cannabinoid cb1 receptor. european journal of pharmacology 584, 338-342 (2008).
[2] pavón, f. j.,serrano, a.,pérez-valero, v., et al. central versus peripheral antagonism of cannabinoid cb1 receptor in obesity: effects of lh-21, a peripherally acting neutral cannabinoid receptor antagonist, in zucker rats. journal of neuroendocrinology 20, 116-123 (2008).

LH 21 Preparation Products And Raw materials

Raw materials

Preparation Products

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LH 21 Suppliers

China 25 United States 3 Global 28
Nanjing ShengSai Chemical Co., Ltd.
Tel
025-85205967 13951876367
Fax
025-85205967
Email
shengsaichem@163.com
Country
China
ProdList
811
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11974
Advantage
58
ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel
13417589054
Email
trendseenbio@gmail.com
Country
China
ProdList
11681
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58

611207-11-5, LH 21Related Search:


  • LH 21
  • LH 21 Exclusive
  • LH21; LH 21
  • 1H-1,2,4-Triazole, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-
  • 611207-11-5
  • C20H20Cl3N3