Wortmannin-Rapamycin Conjugate

Product Name: Wortmannin-Rapamycin Conjugate
CAS No.: 1067892-47-0
Chemical Name: Wortmannin-Rapamycin Conjugate
Synonyms: ATASUAOFUAOSAN-NVEIXTJJSA-N;Wortmannin-Rapamycin Conjugate;Rapamycin, 42-[8-[(1E,4S,4aR,5R,6aS,7S,9aR)-5-(acetyloxy)-1-[[[3-(dimethylamino)propyl]methylamino]methylene]-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydro-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxocyclopenta[5,6]naphtho[1,2-c]pyran-7-yl] octanedioate]
CBNumber: CB42592877
Molecular Formula: C88H131N3O23
Formula Weight: 1598.99
MOL File: 1067892-47-0.mol

More

Less

Wortmannin-Rapamycin Conjugate Property

storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
form: A crystalline solid

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 13671
Product name: Wortmannin-Rapamycin Conjugate
Purity: ≥98%
Packaging: 500μg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 13671
Product name: Wortmannin-Rapamycin Conjugate
Purity: ≥98%
Packaging: 1mg
Price: $288
Updated: 2024/03/01

Cayman Chemical

Product number: 13671
Product name: Wortmannin-Rapamycin Conjugate
Purity: ≥98%
Packaging: 5mg
Price: $1204
Updated: 2024/03/01

AK Scientific

Product number: 1384EN
Product name: 8-O-[(1S,3Ar,6E,9S,9aR,10R,11aS)-10-acetyloxy-6-[[3-(dimethylamino)propyl-methylamino]methylidene]-5-hydroxy-9-(methoxymethyl)-9a,11a-dimethyl-4,7-dioxo-2,3,3a,9,10,11-hexahydro-1H-indeno[4,5-h]isochromen-1-yl]1-O-[(1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,16Z,18R,19R,21R,23S,24Z,26Z,28Z,30S,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl]octanedioate
Packaging: 5mg
Price: $1439
Updated: 2021/12/16

More

Less

Wortmannin-Rapamycin Conjugate Chemical Properties,Usage,Production

Description

Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer. Wortmannin is a potent inhibitor of PI3K enzymes, while rapamycin blocks mTOR Complex 1 TORC1. Wortmannin-rapamycin conjugate consists of analogs of 17-hydroxy wortmannin and rapamycin conjugated via a prodrug linker. Hydrolysis of the prodrug linker in vivo releases the inhibitors. The wortmannin-rapamycin conjugate inhibits the growth of HT-29 colon tumors and A498 renal tumors in mice better than rapamycin alone. Also, the conjugate, when given in combination with the VEGF-blocker bevacizumab, produces substantial regression of larger A498 tumors. Finally, the wortmannin-rapamycin conjugate is tolerated better than an equivalent mixture of the inhibitors.

Wortmannin-Rapamycin Conjugate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Wortmannin-Rapamycin Conjugate Suppliers

China 11 United States 3 Global 14

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

1067892-47-0, Wortmannin-Rapamycin ConjugateRelated Search:

6-amino-8-[3-bromo-5-methoxy-4-(prop-2-en-1-yloxy)phenyl]-8H-[1,3]dioxolo[4,5-g]chromene-7-carbonitrile 8H-1,3-Dioxolo[4,5-g][1]benzopyran-7-carbonitrile, 6-amino-8-(3-bromo-4,5-dimethoxyphenyl)- Wnt/β-catenin agonist 1 3-Isoxazolecarboxamide, 5-(2-furanyl)-N-[2-(1H-pyrazol-1-yl)ethyl]- 3-Isoxazolecarboxamide, 5-(4-fluorophenyl)-N-[3-(1H-imidazol-1-yl)propyl]- Wnt pathway activator 2

Wortmannin-Rapamycin Conjugate

ATASUAOFUAOSAN-NVEIXTJJSA-N

Rapamycin, 42-[8-[(1E,4S,4aR,5R,6aS,7S,9aR)-5-(acetyloxy)-1-[[[3-(dimethylamino)propyl]methylamino]methylene]-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydro-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxocyclopenta[5,6]naphtho[1,2-c]pyran-7-yl] octanedioate]

1067892-47-0

C88H131N3O23