5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine
- Product Name
- 5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine
- CAS No.
- 1266343-30-9
- Chemical Name
- 5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine
- Synonyms
- 7-Bromo-6-chloro-9-methyl-7-deazapurine, 97%;7H-Pyrrolo[2,3-d]pyrimidine, 5-bromo-4-chloro-7-methyl-;JR-14014, 5-Bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine, 95%
- CBNumber
- CB42592998
- Molecular Formula
- C7H5BrClN3
- Formula Weight
- 246.49
- MOL File
- 1266343-30-9.mol
5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine Property
- Boiling point:
- 359.5±37.0 °C(Predicted)
- Density
- 1.90±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Chloroform, Methanol
- form
- Solid
- pka
- 2.45±0.30(Predicted)
- color
- Light Brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B682470
- Product name
- 5-Bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 100mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- B682470
- Product name
- 5-Bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 1g
- Price
- $1260
- Updated
- 2021/12/16
- Product number
- AMTH170
- Product name
- 5-Bromo-4-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 250mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- 076867
- Product name
- 5-Bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- >95%
- Packaging
- 500mg
- Price
- $390
- Updated
- 2021/12/16
- Product number
- AMTH170
- Product name
- 5-Bromo-4-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 1g
- Price
- $430
- Updated
- 2021/12/16
5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine Chemical Properties,Usage,Production
Chemical Properties
5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine is Light Brown Solid
Uses
5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine is used in the preparation of indoline derivatives as PERK inhibitors.
Synthesis
7781-10-4
1266343-30-9
Example 1 Synthesis of 5-(1H-1,3-benzodiazol-2-yl)-7-methyl-N-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine Step 1: Preparation of 5-bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine. To a stirred solution of 4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (6.02 g, 35.9 mmol) in dichloromethane (120 mL) at 0 °C was added N-bromosuccinimide (7.67 g, 43.1 mmol). The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium bicarbonate solution (200 mL) and extracted with dichloromethane (200 mL). The organic layers were combined, dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: dichloromethane/ethyl acetate=10/1) to afford 5-bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (8.27 g, 93% yield) as a white solid.LCMS (Method A) m/z: [M+1]+ 247.9; retention time tR=2.70 min.
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 16, p. 7193 - 7207
[2] Patent: WO2011/18894, 2011, A1. Location in patent: Page/Page column 25-26
[3] Patent: WO2018/194885, 2018, A1. Location in patent: Page/Page column 16
[4] Patent: WO2011/119663, 2011, A1. Location in patent: Page/Page column 82
[5] MedChemComm, 2014, vol. 5, # 10, p. 1500 - 1506
5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine Preparation Products And Raw materials
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View Lastest Price from 5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine manufacturers
- Product
- 5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine 1266343-30-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 98%+
- Supply Ability
- 100kg
- Release date
- 2023-03-02