ChemicalBook > CAS DataBase List > 7-METHYL-1,4-DIOXA-SPIRO[4.5]DECAN-8-ONE

7-METHYL-1,4-DIOXA-SPIRO[4.5]DECAN-8-ONE

Product Name: 7-METHYL-1,4-DIOXA-SPIRO[4.5]DECAN-8-ONE
CAS No.: 702-69-2
Chemical Name: 7-METHYL-1,4-DIOXA-SPIRO[4.5]DECAN-8-ONE
Synonyms: 112530;NSC 113128;7-METHYL-1,4-DIOXA-SPIRO[4.5]DECAN-8-ONE;4,4-(Ethylenedioxy)-2-methylcyclohexanone;)-4,4-Ethylenedioxy-2-methylcyclohexanone;1,4-Dioxaspiro[4.5]decan-8-one, 7-methyl-;5,5-Ethylenedioxy-1-methylcyclohexan-2-one
CBNumber: CB42594301
Molecular Formula: C9H14O3
Formula Weight: 170.21
MOL File: 702-69-2.mol

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7-METHYL-1,4-DIOXA-SPIRO[4.5]DECAN-8-ONE Property

Boiling point:: 98-100℃ (4 Torr)
Density: 1.12±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid
InChI: InChI=1S/C9H14O3/c1-7-6-9(3-2-8(7)10)11-4-5-12-9/h7H,2-6H2,1H3
InChIKey: AFCOTJOAYFEMMV-UHFFFAOYSA-N
SMILES: O1C2(CCC(=O)C(C)C2)OCC1

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Safety

HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M219773
Product name: 7-Methyl-1,4-dioxaspiro[4.5]decan-8-one
Packaging: 500mg
Price: $155
Updated: 2021/12/16

AK Scientific

Product number: 0888AC
Product name: 7-Methyl-1,4-dioxaspiro[4.5]decan-8-one
Packaging: 250mg
Price: $104
Updated: 2021/12/16

AK Scientific

Product number: 0888AC
Product name: 7-Methyl-1,4-dioxaspiro[4.5]decan-8-one
Packaging: 1g
Price: $192
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0391630
Product name: 7-METHYL-1,4-DIOXASPIRO[4.5]DECAN-8-ONE
Purity: 95.00%
Packaging: 5MG
Price: $504.91
Updated: 2021/12/16

AK Scientific

Product number: 0888AC
Product name: 7-Methyl-1,4-dioxaspiro[4.5]decan-8-one
Packaging: 5g
Price: $541
Updated: 2021/12/16

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7-METHYL-1,4-DIOXA-SPIRO[4.5]DECAN-8-ONE Chemical Properties,Usage,Production

Synthesis

4746-97-8

74-88-4

702-69-2

1. A THF solution of 1,4-cyclohexanedione monoethylene glycol ketal (13.90 g, 89.00 mmol) was slowly added to a solution of LHMDS (1.0 M solution of THF, 89.5 mL, 1.0 eq.) in THF (250 mL) over a time period of 15 minutes at -78 °C. 2. the reaction mixture was stirred at -78 °C for 34 min. 3. iodomethane (6.5 mL, 1.2 eq.) was added to the reaction mixture followed by stirring at -78 °C for 20 minutes and then at room temperature for 2 hours. 4. the reaction was quenched by addition of saturated NH4Cl solution (250 mL) and extracted with ether (3 x 250 mL). 5. Combine the organic phases, dry with MgSO4, filter and concentrate in vacuum. 6. 7-methyl-1,4-dioxa-spiro[4.5]decan-8-one (11.16 g, 74% yield) was purified by fast chromatography (eluent: pentane-ether, ratio from 4:1→3:1→2:1). 7. The spectral data of the product were in agreement with those reported in the literature (Pfau, M.; Jabin, I.; Revial, G. J. Chem. Soc, Perkin Trans. 1991, 1935).

References

[1] Angewandte Chemie - International Edition, 2015, vol. 54, # 6, p. 1960 - 1964
[2] Angew. Chem., 2015, vol. 127, # 6, p. 1983 - 1987,5
[3] Journal of the American Chemical Society, 2004, vol. 126, # 44, p. 14358 - 14359
[4] Journal of the American Chemical Society, 2006, vol. 128, # 3, p. 1016 - 1022
[5] Patent: WO2006/19673, 2006, A2. Location in patent: Page/Page column 34; 60

7-METHYL-1,4-DIOXA-SPIRO[4.5]DECAN-8-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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702-69-2, 7-METHYL-1,4-DIOXA-SPIRO[4.5]DECAN-8-ONERelated Search:

dimethylsilanediol

112530

7-METHYL-1,4-DIOXA-SPIRO[4.5]DECAN-8-ONE

)-4,4-Ethylenedioxy-2-methylcyclohexanone

4,4-(Ethylenedioxy)-2-methylcyclohexanone

5,5-Ethylenedioxy-1-methylcyclohexan-2-one

NSC 113128

1,4-Dioxaspiro[4.5]decan-8-one, 7-methyl-

702-69-2