R-1-CBZ-3-Hydroxy-piperidine
- Product Name
- R-1-CBZ-3-Hydroxy-piperidine
- CAS No.
- 100858-34-2
- Chemical Name
- R-1-CBZ-3-Hydroxy-piperidine
- Synonyms
- (R)-1-Cbz-3-hydroxy-piper...;R-1-CBZ-3-Hydroxy-piperidine;benzyl (r)-3-hydroxypiperidine-1-carboxylate;(R)-Benzyl 3-hydroxypiperidine-1-carboxylate;benzyl (3R)-3-hydroxypiperidine-1-carboxylate;1-Piperidinecarboxylic acid, 3-hydroxy-, phenylmethyl ester, (3R)-
- CBNumber
- CB42595353
- Molecular Formula
- C13H17NO3
- Formula Weight
- 235.28
- MOL File
- 100858-34-2.mol
R-1-CBZ-3-Hydroxy-piperidine Property
- Boiling point:
- 384.9±42.0 °C(Predicted)
- Density
- 1.220±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.72±0.20(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0038764
- Product name
- (R)-Benzyl3-hydroxypiperidine-1-carboxylate
- Purity
- >97.0%
- Packaging
- 1g
- Price
- $73
- Updated
- 2021/12/16
- Product number
- 0281AA
- Product name
- (R)-Benzyl3-hydroxypiperidine-1-carboxylate
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- AS55694-3R
- Product name
- (R)-1-Cbz-3-hydroxy-piperidine
- Purity
- 97+% ee
- Packaging
- 1g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 122483
- Product name
- (R)-1-Cbz-3-hydroxy-piperidine
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $166
- Updated
- 2021/12/16
- Product number
- CS-0038764
- Product name
- (R)-Benzyl3-hydroxypiperidine-1-carboxylate
- Purity
- >97.0%
- Packaging
- 5g
- Price
- $225
- Updated
- 2021/12/16
R-1-CBZ-3-Hydroxy-piperidine Chemical Properties,Usage,Production
Synthesis
61995-20-8
100858-34-2
General procedure for the synthesis of (R)-N-CBZ-3-hydroxypiperidine from 1-N-Cbz-3-piperidone: In 1 mL of potassium phosphate buffer (100 mM, pH 7.0), a reaction mixture was prepared by adding 200 mM substrate, 1 mM NAD+, 5% (v/v) 2-propanol, and 10 mg of crude enzyme READH. For ChKRED20, the reaction conditions were adjusted to 40% (v/v) 2-propanol and 40°C reaction temperature. The reaction mixture was warmed at 50 °C (or 40 °C for ChKRED20). The reaction progress was monitored by TLC. Upon completion of the reaction, the reaction was terminated by extraction with 1 mL of methyl tert-butyl ether. The organic phase was dried and concentrated with anhydrous sodium sulfate. The conversion and enantiomeric excess were determined by chiral HPLC. The products were purified by silica gel column chromatography and structurally characterized by NMR analysis, spinometry and mass spectrometry.
References
[1] Process Biochemistry, 2017, vol. 56, p. 90 - 97
R-1-CBZ-3-Hydroxy-piperidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from R-1-CBZ-3-Hydroxy-piperidine manufacturers
- Product
- R-1-CBZ-3-Hydroxy-piperidine 100858-34-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kgs
- Release date
- 2020-02-18