1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Product Name: 1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CAS No.: 1047644-76-7
Chemical Name: 1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Synonyms: 1,4-DiMethylpyrazole-5-boronic Acid Pinacol Ester;(1,4-DIMETHYL-1H-PYRAZOL-5-YL)BORONIC ACID PINACOL ESTER;1,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);1,4-dimethyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyra...;1,4-dimethyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1H-Pyrazole, 1,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber: CB42595535
Molecular Formula: C11H19BN2O2
Formula Weight: 222.09
MOL File: 1047644-76-7.mol

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1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: solid
Appearance: White to off-white Solid
InChI: InChI=1S/C11H19BN2O2/c1-8-7-13-14(6)9(8)12-15-10(2,3)11(4,5)16-12/h7H,1-6H3
InChIKey: NOZSCXDKBYFTBH-UHFFFAOYSA-N
SMILES: N1(C)C(B2OC(C)(C)C(C)(C)O2)=C(C)C=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: D480013
Product name: 1,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole
Packaging: 100mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-W003827
Product name: 1,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Purity: ≥98.0%
Packaging: 250mg
Price: $34
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD141589
Product name: 1,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Packaging: 100mg
Price: $46
Updated: 2021/12/16

ChemScene

Product number: CS-W003827
Product name: 1,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Purity: ≥98.0%
Packaging: 1g
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD141589
Product name: 1,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Packaging: 250mg
Price: $85
Updated: 2021/12/16

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1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Chemical Properties,Usage,Production

Synthesis

1072-68-0

61676-62-8

1047644-76-7

General procedure for the synthesis of 1,4-dimethylpyrazole-5-boronic acid pinacol ester from 1,4-dimethylpyrazole and isopropanol pinacol borate: 1. 1,4-dimethyl-1H-pyrazole (480.0 mg, 4.993 mmol) was dissolved in tetrahydrofuran (20 mL, 300 mmol) at 0 °C and a hexane solution of 1.6 M n-butyllithium (4.7 mL, 7.5 mmol) was slowly added. 2. The reaction solution was stirred at room temperature for 1 hr and then cooled to -78 °C. 3. 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.63 mL, 7.99 mmol) was added to the cooled reaction solution. 4. The reaction mixture was stirred at -78 °C for 0.5 h and then slowly warmed to 0 °C (0.5 h). 5. Upon completion of the reaction, the reaction was quenched with saturated saline and extracted with ethyl acetate (3×). 6. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. 7. The residue was purified by fast column chromatography using a gradient elution of ethyl acetate/hexane (0-60%). 8. Purification afforded 142 mg of the target product 1,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole as a white solid.

References

[1] Patent: WO2008/98104, 2008, A1. Location in patent: Page/Page column 90
[2] Patent: US2013/96144, 2013, A1. Location in patent: Paragraph 0171; 0172
[3] Patent: WO2014/143768, 2014, A1. Location in patent: Page/Page column 109; 110

1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Suppliers

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Changsha Luxing Bio-Chem Technology Co., Ltd.

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View Lastest Price from 1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole manufacturers

Career Henan Chemica Co

Product: 1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1047644-76-7
Price: US $1.00/g
Min. Order: 1g
Purity: 85.0-99.8%
Supply Ability: 20ton
Release date: 2020-10-29

1047644-76-7, 1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleRelated Search:

1,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)

1,4-DiMethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1,4-DiMethylpyrazole-5-boronic Acid Pinacol Ester

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1047644-76-7