5-BroMo-1,2,3-triazine
- Product Name
- 5-BroMo-1,2,3-triazine
- CAS No.
- 114078-88-5
- Chemical Name
- 5-BroMo-1,2,3-triazine
- Synonyms
- 5-bromotriazine;5-BroMo-1,2,3-triazine;1,2,3-Triazine, 5-bromo-
- CBNumber
- CB42595757
- Molecular Formula
- C3H2BrN3
- Formula Weight
- 159.97
- MOL File
- 114078-88-5.mol
5-BroMo-1,2,3-triazine Property
- Melting point:
- 112 °C (decomp)(Solv: ethyl acetate (141-78-6))
- Boiling point:
- 242.5±32.0 °C(Predicted)
- Density
- 1.875±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- -1.31±0.10(Predicted)
- Appearance
- Yellow to brown Solid
- InChI
- InChI=1S/C3H2BrN3/c4-3-1-5-7-6-2-3/h1-2H
- InChIKey
- LSBKXRBABHPHBW-UHFFFAOYSA-N
- SMILES
- N1C=C(Br)C=NN=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B416743
- Product name
- 5-Bromo-1,2,3-triazine
- Packaging
- 2.5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B416743
- Product name
- 5-Bromo-1,2,3-triazine
- Packaging
- 5mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 0191CV
- Product name
- 5-Bromo-1,2,3-triazine
- Packaging
- 50mg
- Price
- $254
- Updated
- 2021/12/16
- Product number
- 0191CV
- Product name
- 5-Bromo-1,2,3-triazine
- Packaging
- 100mg
- Price
- $328
- Updated
- 2021/12/16
- Product number
- CD11347687
- Product name
- 5-Bromo-1,2,3-triazine
- Purity
- 97%
- Packaging
- 100mg
- Price
- $243
- Updated
- 2021/12/16
5-BroMo-1,2,3-triazine Chemical Properties,Usage,Production
Synthesis
122481-11-2
114078-88-5
The general procedure for the synthesis of 5-bromo-1,2,3-triazine using 4-bromo-1H-pyrazol-1-amine as starting material was as follows: dichloromethane (200 mL) and water (76 mL) were added to a reaction flask, and the mixture was cooled to 0 °C with stirring. Subsequently, sodium periodate (29.4 g, 137 mmol) was added in batches. After the addition was completed, the reaction mixture was continued to be stirred at 0°C for 12 hours. After completion of the reaction, the mixture was warmed up to 25 °C for partitioning operation. The aqueous phase was extracted with dichloromethane (100 mL x 3) and all organic phases were combined. The organic phase was washed with saturated brine (250 mL) and then dried with anhydrous sodium sulfate. The dried organic phase was filtered and the filtrate was concentrated to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent ratio of petroleum ether: ethyl acetate= 10:1), and finally 5-bromo-1,2,3-triazine was obtained as a white solid (8.8 g, two-step overall yield 73.5%).
References
[1] Liebigs Annalen der Chemie, 1993, # 4, p. 367 - 374
[2] Chemical & Pharmaceutical Bulletin, 1988, vol. 36, # 10, p. 3838 - 3848
[3] Journal of the American Chemical Society, 2011, vol. 133, # 31, p. 12285 - 12292
[4] Patent: CN105884752, 2016, A. Location in patent: Paragraph 0211; 0212; 0213
[5] Patent: WO2017/35353, 2017, A1. Location in patent: Paragraph 0928
5-BroMo-1,2,3-triazine Preparation Products And Raw materials
Raw materials
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