Gefapixant

ChemicalBook > CAS DataBase List > Gefapixant

Product Name: Gefapixant
CAS No.: 1015787-98-0
Chemical Name: Gefapixant
Synonyms: Gefapixant;MK-7264;MK7264;MK 7264;CS-2846;EOS-6104;EOS-61047;RO-4926219;Gefapixant(AF-219;Gefapixant (MK-7264)
CBNumber: CB42596673
Molecular Formula: C14H19N5O4S
Formula Weight: 353.4
MOL File: 1015787-98-0.mol

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Gefapixant Property

Boiling point:: 606.3±65.0 °C(Predicted)
Density: 1.391±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:38.0(Max Conc. mg/mL);107.53(Max Conc. mM)
form: Solid
pka: 9.90±0.60(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304IF INHALED:

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P362Take off contaminated clothing and wash before reuse.

P403Store in a well-ventilated place.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0021727
Product name: Gefapixant
Purity: 99.62%
Packaging: 5mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BM170818
Product name: MK 7264
Packaging: 10mg
Price: $125
Updated: 2021/12/16

ChemScene

Product number: CS-0021727
Product name: Gefapixant
Purity: 99.62%
Packaging: 10mg
Price: $160
Updated: 2021/12/16

AK Scientific

Product number: 8545BB
Product name: Gefapixant
Packaging: 10mg
Price: $218
Updated: 2021/12/16

ChemScene

Product number: CS-0021727
Product name: Gefapixant
Purity: 99.62%
Packaging: 25mg
Price: $320
Updated: 2021/12/16

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Gefapixant Chemical Properties,Usage,Production

Description

Gefapixant was approved in Japan in 2022 for adult patients with refractory or unexplained chronic cough, marketed under the name Lyfnua.The drug was authorised by the European Medicines Agency (EMA) in September 2023 for the same indication. However, the FDA refused to approve gefapixant for the treatment of adults with refractory or unexplained chronic cough.

Uses

Gefapixant is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC50 values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant can be used for the research of chronic cough and knee osteoarthritis.

Gefapixant Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Gefapixant manufacturers

Career Henan Chemical Co

Product: 5-(2,4-DiaMino-pyriMidin-5-yloxy)-4-isopropyl-2-Methoxy-benzenesulfonaMide 1015787-98-0
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

1015787-98-0, GefapixantRelated Search:

5-(2,4-DiaMino-pyriMidin-5-yloxy)-4-isopropyl-2-Methoxy-benzenesulfonaMide

EOS-61047

EOS-6104

Gefapixant(AF-219,MK-7264)

Gefapixant

RO-4926219

5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)Benzenesulfonamide

Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-

GEFAPIXANT; MK-7264; MK 7264; MK7264; AF-219; AF219; AF 219; RO4926219; RO-4926219; RO 4926219;

GEFAPIXANT;AF-219;MK-7264;AF 219;MK 7264;AF219;MK7264

MK 7264

MK7264

MK-7264

CS-2846

Gefapixant(AF-219

5-[(2,4-Diamino-5-pyrimidinyl)oxy]-4-isopropyl-2-methoxybenzenesulfonamide

Gefapixant,AF-219,MK 7264,inhibit,MK7264,chronic cough,P2X3,knee osteoarthritis,Inhibitor,AF 219,P2X Receptor,P2XRs

Gefapixant (MK-7264)

Gefapixant, 10 mM in DMSO

1015787-98-0

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