AR 231453
- Product Name
- AR 231453
- CAS No.
- 733750-99-7
- Chemical Name
- AR 231453
- Synonyms
- CS-2809;AR 231453;AR231453; AR-231453;AR 231453, 10 mM in DMSO;AR 231453, GPR119 agonist;N-(2-Fluoro-4-(methylsulfonyl)phenyl)-6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5;N-(2-Fluoro-4-(methylsulfonyl)phenyl)-6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-ni;N-(2-Fluoro-4-(methylsulfonyl)phenyl)-6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-amine;inhibit,GPR119,AR-231453,G Protein-Coupled Receptor 119,diabetes,AR231453,AR 231453,insulin,Inhibitor,HIT-T15,glucose,GPCR;(2-FLUORO-4-METHANESULFONYL-PHENYL)-(6-[4-(3-ISOPROPYL-[1,2,4]OXADIAZOL-5-YL)-PIPERIDIN-1-YL]-5-NITRO-PYRIMIDIN-4-YL)-AMINE
- CBNumber
- CB42597458
- Molecular Formula
- C21H24FN7O5S
- Formula Weight
- 505.52
- MOL File
- 733750-99-7.mol
AR 231453 Property
- Melting point:
- 174-176℃
- Boiling point:
- 703.9±70.0 °C(Predicted)
- Density
- 1.421±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 25 mg/ml; DMSO: 3 mg/ml; Ethanol: insol; PBS (pH 7.2): insol
- pka
- 3.24±0.10(Predicted)
- form
- Yellow solid.
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- SML1883
- Product name
- AR231453
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $92.88
- Updated
- 2025/07/31
- Product number
- SML1883
- Product name
- AR231453
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $436
- Updated
- 2025/07/31
- Product number
- BA165448
- Product name
- AR 231453
- Packaging
- 10mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- CS-2475
- Product name
- AR231453
- Purity
- 99.84%
- Packaging
- 10mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- BA165448
- Product name
- AR 231453
- Packaging
- 50mg
- Price
- $465
- Updated
- 2021/12/16
AR 231453 Chemical Properties,Usage,Production
Uses
AR 231453 is a potent, specific and orally available GPR119 agonist. AR 231453 can stimulate β-cell replication and improve islet graft function s[1][2].
Biological Activity
AR231453 is a 5-nitropyrimidine derivative th at acts as a highly potent and selective GPR119 agonist (EC50/GPR119 species = 0.4 nM/monkey, 1.6 nM/dog, 4.7 nM/hamster, 3.5 nM/human, 12 nM/mouse, 4 nM/r at in cell-based assays), exhibiting no off-target activity toward 216 receptors, enzymes, and orphan GPCRs. AR231453 improves glucose tolerance in mice (3 mg/kg i.p. or 20 mg/kg, p.o.) and rats (3 mg/kg i.p.), while no in vivo efficacy is observed among GPR119-deficient mice.
in vivo
AR231453 (20 mg/kg, orally) markedly improves oral glucose tolerance in a dose-dependent fashion, with efficacy similar to maximally effective doses of the sulfonylurea glyburide[1].
| Animal Model: | Mice[1]. |
| Dosage: | 20 mg/kg. |
| Administration: | Orally, once. |
| Result: | Improved glucose tolerance in mice. |
References
[1] Chu ZL, et al. A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology. 2007 Jun;148(6):2601-9. DOI:10.1210/en.2006-1608
[2] J Gao, et al. Stimulating β-cell replication and improving islet graft function by AR231453, A GPR119 agonist. Transplant Proc. 2011 Nov;43(9):3217-20. DOI:10.1016/j.transproceed.2011.10.021
AR 231453 Preparation Products And Raw materials
Raw materials
Preparation Products
AR 231453 Suppliers
- Tel
- --
- Fax
- --
- info@axonmedchem.com
- Country
- The Netherlands
- ProdList
- 477
- Advantage
- 30