AR 231453

Product Name: AR 231453
CAS No.: 733750-99-7
Chemical Name: AR 231453
Synonyms: CS-2809;AR 231453;AR231453; AR-231453;AR 231453, 10 mM in DMSO;AR 231453, GPR119 agonist;N-(2-Fluoro-4-(methylsulfonyl)phenyl)-6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5;N-(2-Fluoro-4-(methylsulfonyl)phenyl)-6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-ni;N-(2-Fluoro-4-(methylsulfonyl)phenyl)-6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-amine;inhibit,GPR119,AR-231453,G Protein-Coupled Receptor 119,diabetes,AR231453,AR 231453,insulin,Inhibitor,HIT-T15,glucose,GPCR;(2-FLUORO-4-METHANESULFONYL-PHENYL)-(6-[4-(3-ISOPROPYL-[1,2,4]OXADIAZOL-5-YL)-PIPERIDIN-1-YL]-5-NITRO-PYRIMIDIN-4-YL)-AMINE
CBNumber: CB42597458
Molecular Formula: C21H24FN7O5S
Formula Weight: 505.52
MOL File: 733750-99-7.mol

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AR 231453 Property

Melting point:: 174-176℃
Boiling point:: 703.9±70.0 °C(Predicted)
Density: 1.421±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 25 mg/ml; DMSO: 3 mg/ml; Ethanol: insol; PBS (pH 7.2): insol
pka: 3.24±0.10(Predicted)
form: Yellow solid.
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1883
Product name: AR231453
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $105
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1883
Product name: AR231453
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $424
Updated: 2024/03/01

Alfa Aesar

Product number: J67299
Product name: AR231453, 98%
Packaging: 5mg
Price: $118
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BA165448
Product name: AR 231453
Packaging: 10mg
Price: $130
Updated: 2021/12/16

ChemScene

Product number: CS-2475
Product name: AR231453
Purity: 99.84%
Packaging: 10mg
Price: $130
Updated: 2021/12/16

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AR 231453 Chemical Properties,Usage,Production

Biological Activity

AR231453 is a 5-nitropyrimidine derivative th at acts as a highly potent and selective GPR119 agonist (EC50/GPR119 species = 0.4 nM/monkey, 1.6 nM/dog, 4.7 nM/hamster, 3.5 nM/human, 12 nM/mouse, 4 nM/r at in cell-based assays), exhibiting no off-target activity toward 216 receptors, enzymes, and orphan GPCRs. AR231453 improves glucose tolerance in mice (3 mg/kg i.p. or 20 mg/kg, p.o.) and rats (3 mg/kg i.p.), while no in vivo efficacy is observed among GPR119-deficient mice.

AR 231453 Preparation Products And Raw materials

Raw materials

Preparation Products

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AR 231453 Suppliers

China 69 The Netherlands 1 United Kingdom 1 United States 12 Global 83

VDM Biochemicals

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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Abcam Limited

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Cayman Chemical Company

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Matrix Scientific

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733750-99-7, AR 231453Related Search:

AR 231453

(2-FLUORO-4-METHANESULFONYL-PHENYL)-(6-[4-(3-ISOPROPYL-[1,2,4]OXADIAZOL-5-YL)-PIPERIDIN-1-YL]-5-NITRO-PYRIMIDIN-4-YL)-AMINE

N-(2-Fluoro-4-(methylsulfonyl)phenyl)-6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-ni

N-(2-Fluoro-4-(methylsulfonyl)phenyl)-6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5

CS-2809

AR231453; AR-231453

N-(2-Fluoro-4-(methylsulfonyl)phenyl)-6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-amine

4-Pyrimidinamine, N-[2-fluoro-4-(methylsulfonyl)phenyl]-6-[4-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-5-nitro-

inhibit,GPR119,AR-231453,G Protein-Coupled Receptor 119,diabetes,AR231453,AR 231453,insulin,Inhibitor,HIT-T15,glucose,GPCR

AR 231453, GPR119 agonist

AR 231453, 10 mM in DMSO

733750-99-7

C21H24FN7O5S

Cannabinoids.

API