ChemicalBook > CAS DataBase List > 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate

Product Name
6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate
CAS No.
288628-05-7
Chemical Name
6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate
Synonyms
STX 64;ST-64667;BN 83495;STX64667;STX 64667;Irosustat;Irosustat(STX64);COUMATE. Irosustat.;DSLPMJSGSBLWRE-UHFFFAOYSA-N;STX64 - BN83495 | Irosustat | 667 Coumate
CBNumber
CB42597564
Molecular Formula
C14H15NO5S
Formula Weight
309.34
MOL File
288628-05-7.mol
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6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Property

Melting point:
170.1-173.4 °C
Boiling point:
544.1±60.0 °C(Predicted)
Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
form 
white powder
pka
8.26±0.70(Predicted)
color 
White to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S1950
Product name
STX64
Purity
≥98% (HPLC)
Packaging
5mg
Price
$211
Updated
2024/03/01
Sigma-Aldrich
Product number
S1950
Product name
STX64
Purity
≥98% (HPLC)
Packaging
25mg
Price
$662
Updated
2024/03/01
TRC
Product number
S687208
Product name
STX64
Packaging
2.5mg
Price
$275
Updated
2021/12/16
Axon Medchem
Product number
Axon2892
Product name
STX64-BN83495|Irosustat|667Coumate
Purity
99%
Packaging
5mg
Price
$99
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0005149
Product name
BN-83495
Purity
95.00%
Packaging
5MG
Price
$728
Updated
2021/12/16
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6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Chemical Properties,Usage,Production

Uses

STX64 is a potent, irreversible inhibitor of steroid sulfatase.

Biochem/physiol Actions

STX64 is a potent, irreversible inhibitor of steroid sulfatase. Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties. STX64 (667 coumate) is a potent tricylic coumarin-based sulfamate that irreversibly inhibits STS activity (IC50 = 8 nM in a placental microsomal assay system). Estrone sulfamate (EMATE) is also a potent STS inhibitor, but has estrogenic activity.

storage

Store at -20°C

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Preparation Products And Raw materials

Raw materials

Preparation Products

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6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Suppliers

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288628-05-7, 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMateRelated Search:


  • 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate
  • BN 83495
  • Irosustat
  • STX 64
  • 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate
  • DSLPMJSGSBLWRE-UHFFFAOYSA-N
  • STX64 - BN83495 | Irosustat | 667 Coumate
  • COUMATE. Irosustat.
  • ST-64667
  • STX 64667
  • STX64; STX-64; STX 64; BN83495; BN-83495; BN 83495; STX 64667; STX64667; ST-64667; COUMATE. IROSUSTAT.
  • STX64667
  • Irosustat(STX64)
  • (6-oxo-8,9,10,11-tetrahydro-7H-cyclohepta[c]chromen-3-yl) sulfamate
  • Sulfamic acid, 6,7,8,9,10,11-hexahydro-6-oxobenzo[b]cyclohepta[d]pyran-3-yl ester
  • BN 83495,Irosustat,Inhibitor,STX-64,STX 64,inhibit,BN-83495
  • 288628-05-7