6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate

Product Name: 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate
CAS No.: 288628-05-7
Chemical Name: 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate
Synonyms: STX 64;ST-64667;BN 83495;STX64667;STX 64667;Irosustat;Irosustat(STX64);COUMATE. Irosustat.;DSLPMJSGSBLWRE-UHFFFAOYSA-N;STX64 - BN83495 | Irosustat | 667 Coumate
CBNumber: CB42597564
Molecular Formula: C14H15NO5S
Formula Weight: 309.34
MOL File: 288628-05-7.mol

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6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Property

Melting point:: 170.1-173.4 °C
Boiling point:: 544.1±60.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >20mg/mL
form: white powder
pka: 8.26±0.70(Predicted)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S1950
Product name: STX64
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $211
Updated: 2024/03/01

Sigma-Aldrich

Product number: S1950
Product name: STX64
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $662
Updated: 2024/03/01

TRC

Product number: S687208
Product name: STX64
Packaging: 2.5mg
Price: $275
Updated: 2021/12/16

Axon Medchem

Product number: Axon2892
Product name: STX64-BN83495|Irosustat|667Coumate
Purity: 99%
Packaging: 5mg
Price: $99
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0005149
Product name: BN-83495
Purity: 95.00%
Packaging: 5MG
Price: $728
Updated: 2021/12/16

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6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Chemical Properties,Usage,Production

Uses

STX64 is a potent, irreversible inhibitor of steroid sulfatase.

Biochem/physiol Actions

STX64 is a potent, irreversible inhibitor of steroid sulfatase. Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties. STX64 (667 coumate) is a potent tricylic coumarin-based sulfamate that irreversibly inhibits STS activity (IC50 = 8 nM in a placental microsomal assay system). Estrone sulfamate (EMATE) is also a potent STS inhibitor, but has estrogenic activity.

storage

Store at -20°C

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Preparation Products And Raw materials

Raw materials

Preparation Products

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6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Suppliers

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288628-05-7, 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMateRelated Search:

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate

BN 83495

Irosustat

STX 64

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate

DSLPMJSGSBLWRE-UHFFFAOYSA-N

STX64 - BN83495 | Irosustat | 667 Coumate

COUMATE. Irosustat.

ST-64667

STX 64667

STX64; STX-64; STX 64; BN83495; BN-83495; BN 83495; STX 64667; STX64667; ST-64667; COUMATE. IROSUSTAT.

STX64667

Irosustat(STX64)

(6-oxo-8,9,10,11-tetrahydro-7H-cyclohepta[c]chromen-3-yl) sulfamate

Sulfamic acid, 6,7,8,9,10,11-hexahydro-6-oxobenzo[b]cyclohepta[d]pyran-3-yl ester

BN 83495,Irosustat,Inhibitor,STX-64,STX 64,inhibit,BN-83495

288628-05-7