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SUMATRIPTAN-D6 HEMISUCCINATE

Product Name
SUMATRIPTAN-D6 HEMISUCCINATE
CAS No.
1397195-80-0
Chemical Name
SUMATRIPTAN-D6 HEMISUCCINATE
Synonyms
SUMATRIPTAN-D6 HEMISUCCINATE;3-[2-[di(methyl-d3)amino]ethyl]-N-methyl-1H-indole-5-methanesulfonamide, butanedioic acid (2:1)
CBNumber
CB4259998
Molecular Formula
C18H27N3O6S
Formula Weight
413.49
MOL File
1397195-80-0.mol
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SUMATRIPTAN-D6 HEMISUCCINATE Property

storage temp. 
Store at -20°C
solubility 
DMSO: soluble
form 
A solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28202
Product name
Sumatriptan-d6 (succinate)
Packaging
1mg
Price
$384
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
RDL0005098
Product name
SUMATRIPTAN-D6 HEMISUCCINATE
Purity
95.00%
Packaging
5MG
Price
$495.1
Updated
2021/12/16
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SUMATRIPTAN-D6 HEMISUCCINATE Chemical Properties,Usage,Production

Biological Activity

Sumatriptan-d6 is intended for use as an internal standard for the quantification of sumatriptan by GC- or LC-MS. Sumatriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 9.3 and 7.3 nM, respectively).1 It also binds to the 5-HT1F receptor (IC50 = 17.8 nM). It induces vasoconstriction in isolated human middle meningeal arteries (EC50 = 89.9 nM), an effect that can be reduced by the 5-HT1B/1D receptor antagonists GR125743 and GR127935 . Sumatriptan reduces acute, but not chronic, mechanical hyperalgesia in a mouse model of pain induced by nitroglycerin, which is a known migraine trigger in humans.2 Formulations containing sumatriptan have been used in the treatment of migraine headache.

References

1.Razzaque, Z., Heald, M.A., Pickard, J.D., et al.Vasoconstriction in human isolated middle meningeal arteries: Determining the contribution of 5-HT1B- and 5-HT1F-receptor activationBr. J. Pharmacol.47(1)75-82(1999) 2.Pradhan, A., Smith, M.L., McGuire, B., et al.Characterization of a novel model of chronic migrainePain155(2)269-274(2014)

SUMATRIPTAN-D6 HEMISUCCINATE Preparation Products And Raw materials

Raw materials

Preparation Products

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SUMATRIPTAN-D6 HEMISUCCINATE Suppliers

ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11217
Advantage
58
Shanghai isotope chemical co.,ltd
Tel
021-021-51600108 13062666369
Email
sales@chinaisotope.com
Country
China
ProdList
4271
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11974
Advantage
58