SUMATRIPTAN-D6 HEMISUCCINATE
- Product Name
- SUMATRIPTAN-D6 HEMISUCCINATE
- CAS No.
- 1397195-80-0
- Chemical Name
- SUMATRIPTAN-D6 HEMISUCCINATE
- Synonyms
- SUMATRIPTAN-D6 HEMISUCCINATE;3-[2-[di(methyl-d3)amino]ethyl]-N-methyl-1H-indole-5-methanesulfonamide, butanedioic acid (2:1)
- CBNumber
- CB4259998
- Molecular Formula
- C18H27N3O6S
- Formula Weight
- 413.49
- MOL File
- 1397195-80-0.mol
SUMATRIPTAN-D6 HEMISUCCINATE Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble
- form
- A solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 28202
- Product name
- Sumatriptan-d6 (succinate)
- Packaging
- 1mg
- Price
- $384
- Updated
- 2024/03/01
- Product number
- RDL0005098
- Product name
- SUMATRIPTAN-D6 HEMISUCCINATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.1
- Updated
- 2021/12/16
SUMATRIPTAN-D6 HEMISUCCINATE Chemical Properties,Usage,Production
Biological Activity
Sumatriptan-d6 is intended for use as an internal standard for the quantification of sumatriptan by GC- or LC-MS. Sumatriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 9.3 and 7.3 nM, respectively).1 It also binds to the 5-HT1F receptor (IC50 = 17.8 nM). It induces vasoconstriction in isolated human middle meningeal arteries (EC50 = 89.9 nM), an effect that can be reduced by the 5-HT1B/1D receptor antagonists GR125743 and GR127935 . Sumatriptan reduces acute, but not chronic, mechanical hyperalgesia in a mouse model of pain induced by nitroglycerin, which is a known migraine trigger in humans.2 Formulations containing sumatriptan have been used in the treatment of migraine headache.
References
1.Razzaque, Z., Heald, M.A., Pickard, J.D., et al.Vasoconstriction in human isolated middle meningeal arteries: Determining the contribution of 5-HT1B- and 5-HT1F-receptor activationBr. J. Pharmacol.47(1)75-82(1999) 2.Pradhan, A., Smith, M.L., McGuire, B., et al.Characterization of a novel model of chronic migrainePain155(2)269-274(2014)
SUMATRIPTAN-D6 HEMISUCCINATE Preparation Products And Raw materials
Raw materials
Preparation Products
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