5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol

Product Name: 5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol
CAS No.: 59281-14-0
Chemical Name: 5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol
Synonyms: 5-benzyloxy-4-hydroxy-2-hydroxymethylpyridine;5-(benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one;2-(hydroxymethyl)-5-(phenylmethoxy)-4(1H)-Pyridinone;4(1H)-Pyridinone, 2-(hydroxymethyl)-5-(phenylmethoxy)-;2-(hydroxymethyl)-5-[(phenylmethyl)oxy]-4-oxo-1,4-dihydropyridine
CBNumber: CB42601180
Molecular Formula: C13H13NO3
Formula Weight: 231.25
MOL File: 59281-14-0.mol

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5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol Property

Boiling point:: 463.4±45.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 9.92±0.69(Predicted)
Appearance: Off-white to gray Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ark Pharm

Product number: AK549013
Product name: 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one
Purity: 97%
Packaging: 1g
Price: $49
Updated: 2021/12/16

Chemenu

Product number: CM253876
Product name: 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one
Purity: 97%
Packaging: 1g
Price: $186
Updated: 2021/12/16

Alichem

Product number: 59281140
Product name: 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one
Packaging: 1g
Price: $192.92
Updated: 2021/12/16

Crysdot

Product number: CD11098149
Product name: 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one
Purity: 97%
Packaging: 5g
Price: $397
Updated: 2021/12/16

Alichem

Product number: 59281140
Product name: 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one
Packaging: 5g
Price: $548.08
Updated: 2021/12/16

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5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol Chemical Properties,Usage,Production

Definition

ChEBI: 5-(benzyloxy)-2-(hydroxymethyl)-1,4-dihydropyridin-4-one is an aromatic ether.

Synthesis

15771-06-9

59281-14-0

5-(Benzyloxy)-2-(hydroxymethyl)-4H-pyran-4-one (53.2 g, 229 mmol) was used as starting material and suspended in a mixed solution of industrial methylated alcohol (IMS, 75 mL) and water (400 mL). To this suspension, NH4OH solution (400 mL) was slowly added at 70 °C and the reaction was continuously stirred for 18 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and subsequently diluted with water (400 mL) and stirring was continued for 30 minutes. The resulting solid product was collected by filtration and dried under vacuum to afford the target compound 5-(benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one (10) as a light brown solid (42.5 g, 80% yield). The product was analyzed by LC-MS showing (M-H)+ = 232. 1H NMR (300 MHz, DMSO-d6) data were as follows: δ 11.08 (br s, 1H), 7.51-7.28 (m, 6H), 6.16 (br s, 1H), 5.56 (br s, 1H), 5.01 (s, 2H), 4.34 (s, 2H).

References

[1] Dalton Transactions, 2016, vol. 45, # 15, p. 6517 - 6528
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 7, p. 2669 - 2684
[3] Patent: WO2017/211759, 2017, A1. Location in patent: Page/Page column 150
[4] Patent: CN106986819, 2017, A. Location in patent: Paragraph 0024-0026; 0028-0030
[5] Patent: CN106986820, 2017, A. Location in patent: Paragraph 0031-0032

5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol Suppliers

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59281-14-0, 5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-olRelated Search:

5-(benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one

2-(hydroxymethyl)-5-(phenylmethoxy)-4(1H)-Pyridinone

2-(hydroxymethyl)-5-[(phenylmethyl)oxy]-4-oxo-1,4-dihydropyridine

4(1H)-Pyridinone, 2-(hydroxymethyl)-5-(phenylmethoxy)-

5-benzyloxy-4-hydroxy-2-hydroxymethylpyridine

59281-14-0