5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol
- Product Name
- 5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol
- CAS No.
- 59281-14-0
- Chemical Name
- 5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol
- Synonyms
- 5-benzyloxy-4-hydroxy-2-hydroxymethylpyridine;5-(benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one;2-(hydroxymethyl)-5-(phenylmethoxy)-4(1H)-Pyridinone;4(1H)-Pyridinone, 2-(hydroxymethyl)-5-(phenylmethoxy)-;2-(hydroxymethyl)-5-[(phenylmethyl)oxy]-4-oxo-1,4-dihydropyridine
- CBNumber
- CB42601180
- Molecular Formula
- C13H13NO3
- Formula Weight
- 231.25
- MOL File
- 59281-14-0.mol
5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol Property
- Boiling point:
- 463.4±45.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 9.92±0.69(Predicted)
- Appearance
- Off-white to gray Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- AK549013
- Product name
- 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- CM253876
- Product name
- 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $186
- Updated
- 2021/12/16
- Product number
- 59281140
- Product name
- 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one
- Packaging
- 1g
- Price
- $192.92
- Updated
- 2021/12/16
- Product number
- CD11098149
- Product name
- 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one
- Purity
- 97%
- Packaging
- 5g
- Price
- $397
- Updated
- 2021/12/16
- Product number
- 59281140
- Product name
- 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one
- Packaging
- 5g
- Price
- $548.08
- Updated
- 2021/12/16
5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol Chemical Properties,Usage,Production
Definition
ChEBI: 5-(benzyloxy)-2-(hydroxymethyl)-1,4-dihydropyridin-4-one is an aromatic ether.
Synthesis
15771-06-9
59281-14-0
5-(Benzyloxy)-2-(hydroxymethyl)-4H-pyran-4-one (53.2 g, 229 mmol) was used as starting material and suspended in a mixed solution of industrial methylated alcohol (IMS, 75 mL) and water (400 mL). To this suspension, NH4OH solution (400 mL) was slowly added at 70 °C and the reaction was continuously stirred for 18 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and subsequently diluted with water (400 mL) and stirring was continued for 30 minutes. The resulting solid product was collected by filtration and dried under vacuum to afford the target compound 5-(benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one (10) as a light brown solid (42.5 g, 80% yield). The product was analyzed by LC-MS showing (M-H)+ = 232. 1H NMR (300 MHz, DMSO-d6) data were as follows: δ 11.08 (br s, 1H), 7.51-7.28 (m, 6H), 6.16 (br s, 1H), 5.56 (br s, 1H), 5.01 (s, 2H), 4.34 (s, 2H).
References
[1] Dalton Transactions, 2016, vol. 45, # 15, p. 6517 - 6528
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 7, p. 2669 - 2684
[3] Patent: WO2017/211759, 2017, A1. Location in patent: Page/Page column 150
[4] Patent: CN106986819, 2017, A. Location in patent: Paragraph 0024-0026; 0028-0030
[5] Patent: CN106986820, 2017, A. Location in patent: Paragraph 0031-0032
5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol Preparation Products And Raw materials
Raw materials
Preparation Products
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