EMD 534085

Product Name: EMD 534085
CAS No.: 858668-07-2
Chemical Name: EMD 534085
Synonyms: CS-1076;EMD 534085;EMD 534085;EMD-534085;EMD534085; EMD-534085; EMD 534085.;1-{[(2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-2H,3H,4H,4aH,5H,6H,10bH-pyrano[3,2-c]quinolin-2-yl]methyl}-3-[2-(dimethylamino)ethyl]urea;1-[[(2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl]methyl]-3-[2-(dimethylamino)ethyl]urea;N-[2-(Dimethylamino)ethyl]-N'-[[(2R,4aS,5R,10bS)-3,4,4a,5,6,10b-hexahydro-5-phenyl-9-(trifluoromethyl)-2H-pyrano[3,2-c]quinolin-2-yl]methyl]urea;Urea, N-[2-(dimethylamino)ethyl]-N'-[[(2R,4aS,5R,10bS)-3,4,4a,5,6,10b-hexahydro-5-phenyl-9-(trifluoromethyl)-2H-pyrano[3,2-c]quinolin-2-yl]methyl]-
CBNumber: CB42602596
Molecular Formula: C25H31F3N4O2
Formula Weight: 476.53
MOL File: 858668-07-2.mol

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EMD 534085 Property

Boiling point:: 609.5±55.0 °C(Predicted)
Density: 1.195
storage temp.: Store at -20°C
solubility: DMSO:26.0(Max Conc. mg/mL);54.56(Max Conc. mM)
form: A solid
pka: 13.78±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6279
Product name: EMD534085
Purity: 99.03%
Packaging: 1mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-6279
Product name: EMD534085
Purity: 99.03%
Packaging: 5mg
Price: $270
Updated: 2021/12/16

ChemScene

Product number: CS-6279
Product name: EMD534085
Purity: 99.03%
Packaging: 10mg
Price: $450
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000565
Product name: EMD 534085
Purity: 95.00%
Packaging: 5MG
Price: $495.64
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb180978
Product name: EMD534085
Purity: >98%
Packaging: 10mg
Price: $838.1
Updated: 2021/12/16

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EMD 534085 Chemical Properties,Usage,Production

Uses

EMD534085 is a potent and selective inhibitor of the mitotic kinesin-5 with an IC50 of 8 nM.

in vivo

In a low dose PK of EMD 534085 in mice the clearance is 1.8 L/h/kg on average, the volume of distribution is 7.4 L/kg and the half life around 2.5 h. The bioavailability in high dose experiments (>10 mg/kg) is always above 50% in mice. Intraperitonal administration of EMD 534085 enables significant systemic exposure in mice leading to a significant tumor growth reduction without toxic side effects^[1].

IC 50

Kinesin-5: 8 nM (IC₅₀)

References

[1] Schiemann K, et al. The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1491-5. DOI:10.1016/j.bmcl.2010.01.110
[2] Tang Y, et al. Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells. Cancer Lett. 2011 Nov 1;310(1):15-24. DOI:10.1016/j.canlet.2011.05.024

EMD 534085 Preparation Products And Raw materials

Raw materials

Preparation Products

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EMD 534085 Suppliers

China 38 United States 5 Global 43

Shanghai Boyle Chemical Co., Ltd.

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Shanghai Biopharmaleader Co., Ltd.

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858668-07-2, EMD 534085Related Search:

EMD 534085

N-[2-(Dimethylamino)ethyl]-N'-[[(2R,4aS,5R,10bS)-3,4,4a,5,6,10b-hexahydro-5-phenyl-9-(trifluoromethyl)-2H-pyrano[3,2-c]quinolin-2-yl]methyl]urea

CS-1076

EMD534085; EMD-534085; EMD 534085.

EMD 534085;EMD-534085

1-[[(2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl]methyl]-3-[2-(dimethylamino)ethyl]urea

Urea, N-[2-(dimethylamino)ethyl]-N'-[[(2R,4aS,5R,10bS)-3,4,4a,5,6,10b-hexahydro-5-phenyl-9-(trifluoromethyl)-2H-pyrano[3,2-c]quinolin-2-yl]methyl]-

1-{[(2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-2H,3H,4H,4aH,5H,6H,10bH-pyrano[3,2-c]quinolin-2-yl]methyl}-3-[2-(dimethylamino)ethyl]urea

858668-07-2