6-broMo-3-iodoH-iMidazo[1,2-a]pyridine
- Product Name
- 6-broMo-3-iodoH-iMidazo[1,2-a]pyridine
- CAS No.
- 474706-74-6
- Chemical Name
- 6-broMo-3-iodoH-iMidazo[1,2-a]pyridine
- Synonyms
- 6-BroMo-3-iodoiMidazo[1,2-a]pyridine;6-broMo-3-iodoH-iMidazo[1,2-a]pyridine;IMidazo[1,2-a]pyridine, 6-broMo-3-iodo-
- CBNumber
- CB42603674
- Molecular Formula
- C7H4BrIN2
- Formula Weight
- 322.93
- MOL File
- 474706-74-6.mol
6-broMo-3-iodoH-iMidazo[1,2-a]pyridine Property
- Melting point:
- 209℃
- Density
- 2.41
- storage temp.
- 2-8°C(protect from light)
- pka
- 2.45±0.50(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C7H4BrIN2/c8-5-1-2-7-10-3-6(9)11(7)4-5/h1-4H
- InChIKey
- VADGFPDSVWQCHR-UHFFFAOYSA-N
- SMILES
- C12=NC=C(I)N1C=C(Br)C=C2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- AK-77962
- Product name
- 6-Bromo-3-iodoimidazo[1,2-a]pyridine
- Purity
- 96%
- Packaging
- 1g
- Price
- $137
- Updated
- 2021/12/16
- Product number
- W6420
- Product name
- 6-Bromo-3-iodoimidazo[1,2-a]pyridine
- Packaging
- 1g
- Price
- $315
- Updated
- 2021/12/16
- Product number
- 071063
- Product name
- 6-Bromo-3-iodoimidazo[1,2-a]pyridine
- Packaging
- 1g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- HCH0367755
- Product name
- 6-BROMO-3-IODOIMIDAZO[1,2-A]PYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.1
- Updated
- 2021/12/16
- Product number
- AK-77962
- Product name
- 6-Bromo-3-iodoimidazo[1,2-a]pyridine
- Purity
- 96%
- Packaging
- 100mg
- Price
- $31
- Updated
- 2021/12/16
6-broMo-3-iodoH-iMidazo[1,2-a]pyridine Chemical Properties,Usage,Production
Synthesis
6188-23-4
474706-74-6
GENERAL STEPS: 6-Bromoimidazo[1,2-a]pyridine (721 mg, 3.66 mmol) was dissolved in 20 mL of acetonitrile (ACN), followed by the addition of N-iodosuccinimide (988 mg, 4.39 mmol). The reaction mixture was stirred at room temperature for 1 hour. After completion of the reaction, the solvent was removed by rotary evaporator under reduced pressure. The residue was dissolved with dichloromethane (CH2Cl2) and washed sequentially with 10% aqueous sodium hydroxide (NaOH), saturated aqueous sodium thiosulfate (Na2S2O3) and deionized water. The organic layer was dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to afford the target compound 6-bromo-3-iodoimidazo[1,2-a]pyridine as a white solid (1.18 g, 96% yield) with a melting point of 209 °C. The product was analyzed by ATR-IR showing characteristic absorption peaks (cm-1): 3024, 1516, 711, 698.1H NMR (400 MHz, CDCl3) δ: 7.29 (dd, J = 9.6, 1.8 Hz, 1H), 7.51 (d, J = 9.6 Hz, 1H), 7.70 (s, 1H), 8.26-8.28 (m, 1H). 1H).13C NMR (100.6 MHz, CDCl3) δ: 61.4, 108.4, 118.6, 126.4, 128.6, 128.6, 141.1, 146.5.High-resolution mass spectrometry (HRMS, EI) m/z calculated value of C7H4BrIN2 [M+H]+: 322.8675, measured value: 322.8678.
References
[1] Tetrahedron, 2011, vol. 67, # 37, p. 7128 - 7138
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 7, p. 2455 - 2466
[3] Patent: WO2008/14219, 2008, A2. Location in patent: Page/Page column 45
[4] Patent: WO2013/147711, 2013, A1. Location in patent: Page/Page column 248
[5] Patent: US2014/371199, 2014, A1. Location in patent: Paragraph 0852
6-broMo-3-iodoH-iMidazo[1,2-a]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
6-broMo-3-iodoH-iMidazo[1,2-a]pyridine Suppliers
- Tel
- 19916721580
- Fax
- QQ：3154870176
- mafarm@126.com
- Country
- China
- ProdList
- 4542
- Advantage
- 58
- Tel
- 021-62219190; 18321139117
- 316441092@qq.com
- Country
- China
- ProdList
- 2907
- Advantage
- 55
- Tel
- 17280940401
- huiyu_bio@126.com
- Country
- China
- ProdList
- 1038
- Advantage
- 58
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 86(512)5235 8471 17715136450
- Fax
- 86(512)5235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 4169
- Advantage
- 58
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9476
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 0513-0513-51005092 13390947892
- Fax
- 0513-51005092
- tashiyxy@163.com
- Country
- China
- ProdList
- 839
- Advantage
- 58
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- sales@ahpharmatech.com
- Country
- China
- ProdList
- 5734
- Advantage
- 55
View Lastest Price from 6-broMo-3-iodoH-iMidazo[1,2-a]pyridine manufacturers
- Product
- 6-broMo-3-iodoH-iMidazo[1,2-a]pyridine 474706-74-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- KG/T
- Release date
- 2019-12-19