4-broMo-5-chlorothiophene-2-carboxylic acid
- Product Name
- 4-broMo-5-chlorothiophene-2-carboxylic acid
- CAS No.
- 60729-37-5
- Chemical Name
- 4-broMo-5-chlorothiophene-2-carboxylic acid
- Synonyms
- 2-Chloro-3-bromo-5-thiophenecarobylic acid;4-broMo-5-chlorothiophene-2-carboxylic acid;4-bromo-5-chloro-2-Thiophenecarboxylic acid;2-Thiophenecarboxylic acid, 4-bromo-5-chloro-
- CBNumber
- CB42606105
- Molecular Formula
- C5H2BrClO2S
- Formula Weight
- 241.49
- MOL File
- 60729-37-5.mol
4-broMo-5-chlorothiophene-2-carboxylic acid Property
- Melting point:
- >200 °C
- Boiling point:
- 342.3±42.0 °C(Predicted)
- Density
- 2.019±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- powder
- pka
- 3.31±0.10(Predicted)
- color
- White
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P000028774
- Product name
- 4-Bromo-5-chlorothiophene-2-carboxylic acid
- Purity
- 96%
- Packaging
- 100mg
- Price
- $131
- Updated
- 2021/12/16
- Product number
- OR31657
- Product name
- 4-Bromo-5-chlorothiophene-2-carboxylicacid
- Purity
- 98%
- Packaging
- 250mg
- Price
- $174
- Updated
- 2021/12/16
- Product number
- P000028774
- Product name
- 4-Bromo-5-chlorothiophene-2-carboxylic acid
- Purity
- 96%
- Packaging
- 250mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- OR31657
- Product name
- 4-Bromo-5-chlorothiophene-2-carboxylicacid
- Purity
- 98%
- Packaging
- 1g
- Price
- $522
- Updated
- 2021/12/16
- Product number
- HCH0365706
- Product name
- 4-BROMO-5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $525
- Updated
- 2021/12/16
4-broMo-5-chlorothiophene-2-carboxylic acid Chemical Properties,Usage,Production
Synthesis
24065-33-6
60729-37-5
The general procedure for the synthesis of 4-bromo-5-chlorothiophene-2-carboxylic acid from 2-chlorothiophene-5-carboxylic acid was as follows: a solution of bromine (634 μL, 12.3 mmol) in acetic acid (2.5 mL) was added slowly and dropwise to an acetic acid solution (25 mL) containing 5-chloro-2-thiophenecarboxylic acid (2 g, 12.3 mmol) and ferric chloride (399 mg, 2.50 mmol). mL) at 25 °C. Subsequently, the reaction mixture was heated to reflux during which bromine (634 μL, 12.3 mmol) and ferric chloride (399 mg, 2.50 mmol) were added in portions. After the reaction lasted for 7 days, the reaction solution was poured into ice water, the precipitate precipitated was filtered and washed with cold water to finally obtain 4-bromo-5-chlorothiophene-2-carboxylic acid (3 g, quantitative yield) as a yellow powder. The product was analyzed by liquid chromatography-mass spectrometry (LC-MS) and showed m/z 242 ([M+H]+).
References
[1] Patent: WO2008/98104, 2008, A1. Location in patent: Page/Page column 81-82
4-broMo-5-chlorothiophene-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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