4-broMo-5-chlorothiophene-2-carboxylic acid

4-broMo-5-chlorothiophene-2-carboxylic acid Property

Melting point:

>200 °C

Boiling point:

342.3±42.0 °C(Predicted)

Density 

2.019±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

powder

pka

3.31±0.10(Predicted)

color 

White

Safety

HS Code 

2934999090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

4-broMo-5-chlorothiophene-2-carboxylic acid Chemical Properties,Usage,Production

Synthesis

The general procedure for the synthesis of 4-bromo-5-chlorothiophene-2-carboxylic acid from 2-chlorothiophene-5-carboxylic acid was as follows: a solution of bromine (634 μL, 12.3 mmol) in acetic acid (2.5 mL) was added slowly and dropwise to an acetic acid solution (25 mL) containing 5-chloro-2-thiophenecarboxylic acid (2 g, 12.3 mmol) and ferric chloride (399 mg, 2.50 mmol). mL) at 25 °C. Subsequently, the reaction mixture was heated to reflux during which bromine (634 μL, 12.3 mmol) and ferric chloride (399 mg, 2.50 mmol) were added in portions. After the reaction lasted for 7 days, the reaction solution was poured into ice water, the precipitate precipitated was filtered and washed with cold water to finally obtain 4-bromo-5-chlorothiophene-2-carboxylic acid (3 g, quantitative yield) as a yellow powder. The product was analyzed by liquid chromatography-mass spectrometry (LC-MS) and showed m/z 242 ([M+H]+).

References

[1] Patent: WO2008/98104, 2008, A1. Location in patent: Page/Page column 81-82