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6-chloroisoquinolin-1(2H)-one

Product Name
6-chloroisoquinolin-1(2H)-one
CAS No.
131002-09-0
Chemical Name
6-chloroisoquinolin-1(2H)-one
Synonyms
6-chloroisoquinolin-1-ol;6-chloro-1-isoquinolinone;6-chloro-2H-isoquinolin-1-one;6-chloro-1(2H)-Isoquinolinone;6-chloroisoquinolin-1(2H)-one;1(2H)-Isoquinolinone, 6-chloro-;6-chloro-1,2-dihydroisoquinolin-1-one
CBNumber
CB42606211
Molecular Formula
C9H6ClNO
Formula Weight
179.6
MOL File
131002-09-0.mol
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6-chloroisoquinolin-1(2H)-one Property

Boiling point:
430.4±45.0 °C(Predicted)
Density 
1.339±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
12.06±0.20(Predicted)
Appearance
Off-white to light yellow Solid
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Safety

HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
C383830
Product name
6-Chloroisoquinolin-1-ol
Packaging
50mg
Price
$155
Updated
2021/12/16
Apolloscientific
Product number
OR917233
Product name
6-Chloroisoquinolin-1-ol
Purity
98%
Packaging
1g
Price
$310
Updated
2021/12/16
AK Scientific
Product number
Y5260
Product name
6-Chloroisoquinolin-1-ol
Packaging
5g
Price
$784
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0036515
Product name
6-CHLORO-1(2H)-ISOQUINOLINONE
Purity
95.00%
Packaging
5G
Price
$909.56
Updated
2021/12/16
AK Scientific
Product number
Y5260
Product name
6-Chloroisoquinolin-1-ol
Packaging
250mg
Price
$149
Updated
2021/12/16
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6-chloroisoquinolin-1(2H)-one Chemical Properties,Usage,Production

Synthesis

22246-02-2

131002-09-0

6-Chloro-3,4-dihydro-2H-isoquinolin-1-one (181.5 mg, 1 mmol, Intermediate A-2) was used as a feedstock and mixed with DDQ (227 mg, 1 mmol) in dioxane (3 mL) and the reaction was carried out at reflux overnight. After completion of the reaction, the mixture was cooled to room temperature and treated with saturated aqueous NaHCO3 solution. Subsequently, the reaction mixture was extracted with ethyl acetate (2 x 10 mL). The organic layers were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by rapid chromatography on silica gel to afford 6-chloro-1-isoquinolinone (108 mg, 60% yield) as a white solid. Mass spectrometry (MS) analysis showed a molecular ion peak of 180.0 (M + H+).

References

[1] Patent: WO2013/79452, 2013, A1. Location in patent: Page/Page column 133

6-chloroisoquinolin-1(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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6-chloroisoquinolin-1(2H)-one Suppliers

China 44 India 1 United States 1 Global 46
Accela ChemBio Co.,Ltd.
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021-50795510 4000665055
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ZEROSCHEM.CO.,LTD.
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China
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Chimica Laboratories Co., Ltd
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Shanghai Carlow Chemicals Co., Ltd.
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Changzhou Hopschain Chemical Co.,Ltd.
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Shanghai SuperLan Chemcial Technique Centre
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China
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View Lastest Price from 6-chloroisoquinolin-1(2H)-one manufacturers

Career Henan Chemical Co
Product
6-chloroisoquinolin-1(2H)-one 131002-09-0
Price
US $5.50/KG
Min. Order
1KG
Purity
98%min
Supply Ability
1kg-100kg
Release date
2020-01-14

131002-09-0, 6-chloroisoquinolin-1(2H)-oneRelated Search:

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  • 6-chloroisoquinolin-1(2H)-one
  • 6-chloroisoquinolin-1-ol
  • 6-chloro-1(2H)-Isoquinolinone
  • 6-chloro-2H-isoquinolin-1-one
  • 6-chloro-1,2-dihydroisoquinolin-1-one
  • 6-chloro-1-isoquinolinone
  • 1(2H)-Isoquinolinone, 6-chloro-
  • 131002-09-0