5-cyano-2-fluorobenzene-1-sulfonyl chloride
- Product Name
- 5-cyano-2-fluorobenzene-1-sulfonyl chloride
- CAS No.
- 1101120-80-2
- Chemical Name
- 5-cyano-2-fluorobenzene-1-sulfonyl chloride
- Synonyms
- 5-Cyano-2-fluorobenzenesulfonyl chloride;Benzenesulfonyl chloride, 5-cyano-2-fluoro-;2-Fluoro-5-cyanobenzene-1-sulfonyl chloride;5-cyano-2-fluorobenzene-1-sulfonyl chloride
- CBNumber
- CB42609984
- Molecular Formula
- C7H3ClFNO2S
- Formula Weight
- 219.62
- MOL File
- 1101120-80-2.mol
5-cyano-2-fluorobenzene-1-sulfonyl chloride Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2904990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- C998635
- Product name
- 5-Cyano-2-fluorobenzene-1-sulfonylChloride
- Packaging
- 500mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 119800
- Product name
- 5-Cyano-2-fluorobenzene-1-sulfonyl chloride
- Purity
- 95+%
- Packaging
- 1g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- HCH0367352
- Product name
- 5-CYANO-2-FLUOROBENZENE-1-SULFONYL CHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.92
- Updated
- 2021/12/16
- Product number
- 119800
- Product name
- 5-Cyano-2-fluorobenzene-1-sulfonyl chloride
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1170
- Updated
- 2021/12/16
- Product number
- 1928AA
- Product name
- 5-Cyano-2-fluorobenzene-1-sulfonylchloride
- Packaging
- 10g
- Price
- $1651
- Updated
- 2021/12/16
5-cyano-2-fluorobenzene-1-sulfonyl chloride Chemical Properties,Usage,Production
Synthesis
859855-53-1
1101120-80-2
General procedure for the synthesis of 2-fluoro-5-cyanobenzenesulfonyl chloride from 3-amino-4-fluorobenzonitrile: An aqueous solution (2 mL) of NaNO2 (380 mg, 5.51 mmol) was slowly added to a suspension of 3-amino-4-fluorobenzonitrile (500 mg, 3.67 mmol) in concentrated HCl (5 mL) at 0 °C. The reaction mixture was kept stirred at 0 °C for 30 min. Meanwhile, SO2-saturated AcOH solution (5 mL) was prepared, followed by the addition of CuCl2-2H2O (188 mg, 1.10 mmol) and continued to pass SO2 gas for 5 min. This AcOH mixture was cooled to 5 °C and then the diazonium salt solution prepared as previously described was added over 5 min. The reaction mixture was continued to be stirred at 0°C for 1 hour, followed by warming up to room temperature and stirring for another 1 hour. After completion of the reaction, the mixture was diluted with water and extracted twice with CH2Cl2. The organic phases were combined, washed twice with water, dried over Na2SO4 and concentrated under reduced pressure to remove the solvent. Purification by column chromatography (eluent: hexane/EtOAc, 19:1 to 9:1 gradient elution) afforded 2-fluoro-5-cyanobenzenesulfonyl chloride as a yellow oil (569 mg, 71% yield).1H NMR (400 MHz, CDCl3) δ 8.31 (dd, J = 6.2, 2.1 Hz, 1H), 8.04 (dd, J = 8.7, 4.3, 2.1 Hz), 8.04 (ddd, J = 8.7, 4.3, 2.1 Hz). 4.3, 2.1 Hz, 1H), 7.51 (t, J = 8.7 Hz, 1H).LCMS (APCI-) m/z 200 ([M-Cl+O]-, 100%).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 2, p. 187 - 190
[2] European Journal of Medicinal Chemistry, 2013, vol. 65, p. 32 - 40
5-cyano-2-fluorobenzene-1-sulfonyl chloride Preparation Products And Raw materials
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