Cilengitide trifluoroacetate

Product Name: Cilengitide trifluoroacetate
CAS No.: 199807-35-7
Chemical Name: Cilengitide trifluoroacetate
Synonyms: Cilengitide TFA;cyclo[RGDf(N-Me-Val);Cilengitide (TFA salt);EMD 121974; NSC 707544;EMD 121974 trifluoroacetate;Cilengitide trifluoroacetate;Cilengitide TFA (EMD 121974);2-((2S,5R,8S,11S)-5-Benzyl-11-(3-guanidinopropyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid trifluoroacetate
CBNumber: CB42610252
Molecular Formula: C29H41F3N8O9
Formula Weight: 702.6792496
MOL File: 199807-35-7.mol

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Cilengitide trifluoroacetate Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);142.31(Max Conc. mM)
Water:15.63(Max Conc. mg/mL);22.24(Max Conc. mM)
form: Solid
color: White to off-white
Water Solubility: Water: 25 mg/mL (35.58 mM)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 7746EJ
Product name: Cilengitidetrifluoroacetate
Packaging: 1mg
Price: $141
Updated: 2021/12/16

ChemScene

Product number: CS-0006160
Product name: CilengitideTFA
Purity: 98.85%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0006160
Product name: CilengitideTFA
Purity: 98.85%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0006160
Product name: CilengitideTFA
Purity: 98.85%
Packaging: 25mg
Price: $450
Updated: 2021/12/16

Ambeed

Product number: A253683
Product name: Cilengitidetrifluoroacetate
Purity: 98%
Packaging: 1mg
Price: $27
Updated: 2021/12/16

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Cilengitide trifluoroacetate Chemical Properties,Usage,Production

Uses

Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptor, with IC50 values of 4 nM and 79 nM, respectively.

in vivo

In nude mice bearing M21-L melanoma tumors, Cilengitide dose i.p. at 10, 50, and 250 μg three times per week demonstrate inhibition of tumor growth with a reduction in both tumor volume (55%, 75%, and 89%, respectively) and tumor weight (23%, 38%, and 61%, respectively), when compared to controls^[2]. In the rat model studied, the systemic pharmacokinetics of i.p. Cilengitide are not affected by ILP with Cilengitide alone or ILP with Cilengitide plus Melphalan, TNF or both. Systemic Cilengitide levels reach around 20 μg/mL (approximately 35 μM) within 10 min of i.p. administration and continued to rise to approximately 40 μg/mL (approximately 70 μM) in the first hour. Thereafter Cilengitide levels in serum drop with an elimination half-life of 2.1 hr^[3].

References

[1] Hariharan S, et al. Assessment of the biological and pharmacological effects of the alpha nu beta3 and alpha nu beta5 integrinreceptor antagonist, Cilengitide (EMD 121974), in patients with advanced solid tumors. Ann Oncol. 2007 Aug;18(8):1400-7. DOI:10.1093/annonc/mdm140
[2] Kim YH, et al. Combination therapy of cilengitide with belotecan against experimental glioblastoma. Int J Cancer. 2013 Aug 1;133(3):749-56. DOI:10.1002/ijc.28058
[3] Ten Hagen TL, et al. The αVβ3/αVβ5 integrin inhibitor cilengitide augments tumor response to melphalan isolated limb perfusion in a sarcoma model. Int J Cancer. 2012 Nov 13. DOI:10.1002/ijc.27940

Cilengitide trifluoroacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Cilengitide trifluoroacetate Suppliers

China 49 India 1 Japan 1 United States 7 Global 58

Alabiochem Tech.Co., Ltd.

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Amadis Chemical Company Limited

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Beijing Jin Ming Biotechnology Co., Ltd.

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View Lastest Price from Cilengitide trifluoroacetate manufacturers

Career Henan Chemical Co

Product: Cilengitide trifluoroacetate 199807-35-7
Price: US $1.00/g
Min. Order: 1g
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-10

199807-35-7, Cilengitide trifluoroacetateRelated Search:

Cilengitide trifluoroacetate

Cilengitide (TFA salt)

EMD 121974 trifluoroacetate

EMD 121974; NSC 707544

Cilengitide TFA

Cilengitide TFA (EMD 121974)

2-((2S,5R,8S,11S)-5-Benzyl-11-(3-guanidinopropyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid trifluoroacetate

cyclo[RGDf(N-Me-Val)

199807-35-7

C29H41F3N8O9