ChemicalBook > CAS DataBase List > 2-chloro-4-iodopyrimidine

2-chloro-4-iodopyrimidine

Product Name
2-chloro-4-iodopyrimidine
CAS No.
395082-55-0
Chemical Name
2-chloro-4-iodopyrimidine
Synonyms
2-chloro-4-iodopyrimidine;Pyrimidine, 2-chloro-4-iodo-
CBNumber
CB42617534
Molecular Formula
C4H2ClIN2
Formula Weight
240.43
MOL File
395082-55-0.mol
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2-chloro-4-iodopyrimidine Property

Melting point:
111.3-112.4 °C
Boiling point:
317.8±15.0 °C(Predicted)
Density 
2.187±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
-2.88±0.20(Predicted)
InChI
InChI=1S/C4H2ClIN2/c5-4-7-2-1-3(6)8-4/h1-2H
InChIKey
LOPQDJJEZFCJMU-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC(I)=N1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
1994AQ
Product name
2-chloro-4-iodopyrimidine
Packaging
100mg
Price
$179.6
Updated
2021/12/16
Chemenu
Product number
CM252706
Product name
2-Chloro-4-iodopyrimidine
Purity
95%
Packaging
1g
Price
$294
Updated
2021/12/16
Crysdot
Product number
CD11130263
Product name
2-Chloro-4-iodopyrimidine
Purity
95+%
Packaging
1g
Price
$311
Updated
2021/12/16
Alichem
Product number
395082550
Product name
2-Chloro-4-iodopyrimidine
Packaging
250mg
Price
$898.6
Updated
2021/12/16
Crysdot
Product number
CD11130263
Product name
2-Chloro-4-iodopyrimidine
Purity
95+%
Packaging
5g
Price
$932
Updated
2021/12/16
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2-chloro-4-iodopyrimidine Chemical Properties,Usage,Production

Description

2-Chloro-4-iodopyrimidine is an inhibitor of protein kinases. It binds to the ATP site of a kinase and inhibits its activity by forming a covalent bond with the serine or threonine residue of the active site. 2-Chloro-4-iodopyrimidine has been shown to inhibit tumor cell proliferation and induce apoptosis in vitro and in vivo. This compound has been shown to inhibit the activity of family kinases, including those involved in tumor growth and angiogenesis.

Preparation

The raw material and cuprous iodide are homogeneously mixed in acetonitrile. Add tert-butyl nitroso ester at -2 °C and stir for 5 min to heat the reaction to 73 °C. After 3h of the reaction, the raw material reaction was completed by TLC detection, cooled to room temperature, and water and saturated sodium carbonate solution were added to the reaction. Finally, the product is purified to obtain the product

2-chloro-4-iodopyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-chloro-4-iodopyrimidine Suppliers

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395082-55-0, 2-chloro-4-iodopyrimidineRelated Search:


  • 2-chloro-4-iodopyrimidine
  • Pyrimidine, 2-chloro-4-iodo-
  • 395082-55-0