ChemicalBook > CAS DataBase List > 2-chloro-4-iodopyrimidine
2-chloro-4-iodopyrimidine
- Product Name
- 2-chloro-4-iodopyrimidine
- CAS No.
- 395082-55-0
- Chemical Name
- 2-chloro-4-iodopyrimidine
- Synonyms
- 2-chloro-4-iodopyrimidine;Pyrimidine, 2-chloro-4-iodo-
- CBNumber
- CB42617534
- Molecular Formula
- C4H2ClIN2
- Formula Weight
- 240.43
- MOL File
- 395082-55-0.mol
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2-chloro-4-iodopyrimidine Property
- Melting point:
- 111.3-112.4 °C
- Boiling point:
- 317.8±15.0 °C(Predicted)
- Density
- 2.187±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -2.88±0.20(Predicted)
- InChI
- InChI=1S/C4H2ClIN2/c5-4-7-2-1-3(6)8-4/h1-2H
- InChIKey
- LOPQDJJEZFCJMU-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(I)=N1
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
AK Scientific
- Product number
- 1994AQ
- Product name
- 2-chloro-4-iodopyrimidine
- Packaging
- 100mg
- Price
- $179.6
- Updated
- 2021/12/16
Chemenu
- Product number
- CM252706
- Product name
- 2-Chloro-4-iodopyrimidine
- Purity
- 95%
- Packaging
- 1g
- Price
- $294
- Updated
- 2021/12/16
Crysdot
- Product number
- CD11130263
- Product name
- 2-Chloro-4-iodopyrimidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $311
- Updated
- 2021/12/16
Alichem
- Product number
- 395082550
- Product name
- 2-Chloro-4-iodopyrimidine
- Packaging
- 250mg
- Price
- $898.6
- Updated
- 2021/12/16
Crysdot
- Product number
- CD11130263
- Product name
- 2-Chloro-4-iodopyrimidine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $932
- Updated
- 2021/12/16
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2-chloro-4-iodopyrimidine Chemical Properties,Usage,Production
Description
2-Chloro-4-iodopyrimidine is an inhibitor of protein kinases. It binds to the ATP site of a kinase and inhibits its activity by forming a covalent bond with the serine or threonine residue of the active site. 2-Chloro-4-iodopyrimidine has been shown to inhibit tumor cell proliferation and induce apoptosis in vitro and in vivo. This compound has been shown to inhibit the activity of family kinases, including those involved in tumor growth and angiogenesis.
Preparation
The raw material and cuprous iodide are homogeneously mixed in acetonitrile. Add tert-butyl nitroso ester at -2 °C and stir for 5 min to heat the reaction to 73 °C. After 3h of the reaction, the raw material reaction was completed by TLC detection, cooled to room temperature, and water and saturated sodium carbonate solution were added to the reaction. Finally, the product is purified to obtain the product
2-chloro-4-iodopyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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