ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate
- Product Name
- ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate
- CAS No.
- 51656-91-8
- Chemical Name
- ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate
- Synonyms
- NSC 649463;Aceticacid, 1,4-dioxaspiro[4.5;Ethyl 1,4-dioxaspiro[4.5]dec-8-ylideneacetate;ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate;ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate-24;8-[(Ethoxycarbonyl)methylidene]-1,4-dioxaspiro[4.5]decane;4-(4-oxo-1-cyclohexa-2,5-dienylidene)-1-cyclohexa-2,5-dienone;2-(1,4-Dioxaspiro[4.5]decan-8-ylidene)acetic acid ethyl ester;Acetic acid, 2-(1,4-dioxaspiro[4.5]dec-8-ylidene)-, ethyl ester
- CBNumber
- CB42619336
- Molecular Formula
- C12H18O4
- Formula Weight
- 226.27
- MOL File
- 51656-91-8.mol
ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate Property
- Boiling point:
- 327.8±42.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E917418
- Product name
- Ethyl2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-M1349
- Product name
- ethyl2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-M1349
- Product name
- ethyl2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate
- Packaging
- 1g
- Price
- $99
- Updated
- 2021/12/16
- Product number
- OR46595
- Product name
- Ethyl1,4-dioxaspiro[4.5]dec-8-ylideneacetate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $118
- Updated
- 2021/12/16
- Product number
- 2H23-1-65
- Product name
- Ethyl1,4-dioxaspiro[4.5]dec-8-ylideneacetate
- Purity
- 95.0%
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate Chemical Properties,Usage,Production
Synthesis
4746-97-8
51656-91-8
The general procedure for the synthesis of ethyl 2-(1,4-dioxaspiro[4.5]dec-8-ylidene)acetate from 1,4-cyclohexanedione monoethyleneglycol ketal was carried out as follows: triethyl phosphonate (44.8 g, 200 mmol) was dissolved in THF (30 ml) at 0 °C, followed by the addition of a 1 M solution of sodium bis(trimethylmethylsilylamino)THF (200 ml). The reaction mixture was stirred at room temperature for 0.5 h and then cooled to 0°C again. A solution of 1,4-cyclohexanedione monoethylene glycol ketal (15.6 g, 200 mmol) in THF (50 ml) was added slowly dropwise. After the dropwise addition, the reaction solution was continued to be stirred at room temperature for 18 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and the reaction was quenched with cold aqueous citric acid, followed by extraction with EtOAc. The organic phase was washed sequentially with saturated aqueous NaHCO3 solution, brine and dried with Na2SO4. The dried organic phase was filtered and concentrated, and the crude product obtained was purified by silica gel column chromatography with CH2Cl2/EtOAc gradient elution to finally obtain the target product, ethyl 2-(1,4-dioxaspiro[4.5]deca-8-ylidene)acetate (21 g, 91% yield).
References
[1] Patent: US2006/264489, 2006, A1. Location in patent: Page/Page column 77-78
[2] Patent: US5877199, 1999, A
[3] Patent: WO2006/115168, 2006, A1. Location in patent: Page/Page column 106-107
[4] Patent: WO2007/73934, 2007, A1. Location in patent: Page/Page column 92-93
[5] Patent: WO2004/99191, 2004, A2. Location in patent: Page 17
ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate Preparation Products And Raw materials
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