1-[2-(3,4-Dichlorophenyl)ethyl]-4-Methylpiperazine Dihydrochloride

ChemicalBook > CAS DataBase List > 1-[2-(3,4-Dichlorophenyl)ethyl]-4-Methylpiperazine Dihydrochloride

1-[2-(3,4-Dichlorophenyl)ethyl]-4-Methylpiperazine Dihydrochloride

Product Name: 1-[2-(3,4-Dichlorophenyl)ethyl]-4-Methylpiperazine Dihydrochloride
CAS No.: 206996-13-6
Chemical Name: 1-[2-(3,4-Dichlorophenyl)ethyl]-4-Methylpiperazine Dihydrochloride
Synonyms: BD1063 HCl;BD 1063 (hydrochloride);BD1063 (dhydrochloride);BD-1063 DHYDROCHLORIDE; BD 1063 DHYDROCHLORIDE;1-(3,4-Dichlorophenethyl)-4-methylpiperazine dihydrochloride;Sigma Receptor,Inhibitor,inhibit,BD1063 dhydrochloride,BD-1063 dhydrochloride
CBNumber: CB42620871
Molecular Formula: C13H19Cl3N2
Formula Weight: 309.66
MOL File: 206996-13-6.mol

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1-[2-(3,4-Dichlorophenyl)ethyl]-4-Methylpiperazine Dihydrochloride Property

storage temp.: room temp
solubility: H2O: >15mg/mL
form: powder
color: white to beige
Water Solubility: Soluble to 100 mM in water
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0276
Product name: BD 1063 dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $113
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0276
Product name: BD 1063 dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $441
Updated: 2024/03/01

Cayman Chemical

Product number: 23874
Product name: BD 1063 (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 23874
Product name: BD 1063 (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

TRC

Product number: B129470
Product name: BD 1063 dihydrochloride
Packaging: 5mg
Price: $70
Updated: 2021/12/16

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1-[2-(3,4-Dichlorophenyl)ethyl]-4-Methylpiperazine Dihydrochloride Chemical Properties,Usage,Production

Description

BD1063 (206996-13-6) is potent and selective sigma-1 antagonist (IC50’s: σ1 = 9nM, σ2 = 449nM).1?BD1063 abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by enhancing the action of endogenous opioid peptides of immune origin in a σ1 dependent manner.2?BD1063 potentiated μ-opioid antinociception in mice in a sigma-dependent manner.3?BD-1063 has been used in animal models to successfully treat compulsive eating4?and excessive ethanol drinking5.

Chemical Properties

White Solid

Uses

BD 1063 dihydrochloride has been used as a sigma-1 receptor (S1R) antagonist:

to study the in vitro and in vivo protective action of S1R against ferroptosis in hepatocellular carcinoma cells
in a comparative evaluation of its anti-hyperalgesic action with that of the effects of N-(2-morpholin-4-yl-ethyl)-2-(1-naphthyloxy) acetamide (NMIN) in a chronic constriction injury model (CCI)
to study the contribution of sigma receptors inhibition to the neuroprotective effects of memantine against amyloid-beta (Aβ)-induced neurotoxicity in SH-SY5Y cells

Uses

The novel σ receptor ligands

Biochem/physiol Actions

BD 1063 is a potent sigma(1) receptor antagonist; approximately 50-fold selective for sigma-1 over sigma-2 and 100-fold or more selective over 9 other tested neurotransmitter receptors. BD 1063 has been shown to antagonize cocaine efffects.

in vivo

BD1063 dose-dependently reduces ethanol self-administration in sP rats (3.3-11 mg/kg) and withdrawn, dependent Wistar rats (4-11 mg/kg) at doses that does not modify mean ethanol self-administration in non-dependent Wistar controls. BD1063 also reduces the breakpoints of sP rats to work for ethanol under a progressive-ratio reinforcement schedule. BD1063 dose-dependently reduces binge-like eating and the regularity of food responding, and blocks the increased eating rate in Palatable rats. In the light/dark conflict test, BD1063 antagonizes the increased time spent in the aversive compartment and the increased intake of the palatable diet, without affecting motor activity. The administration of BD1063 30 minutes before each paclitaxel dose prevents the development of cold and mechanical allodynia in WT mice. Moreover, the acute administration of BD1063 dose dependently reverses both types of paclitaxel-induced allodynia.

storage

Store at RT

References

1) Matsumoto?et al.?(1995),?Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest &sigma receptor antagonism; Eur. J. Pharmacol.?280?301 2) Tejada?et al.?(2017),?Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice; Proc. Natl. Acad. Sci. USA?114?8396 3) Sanchez-Fernandez?et al.?(2014),?Modulation of peripheral μ-opioid analgesia by σ1 receptors; J. Pharmacol. Exp. Ther.?348?32 4) Cottone?et al.?(2012),?Antagonism of sigma-1 receptors blocks compulsive-like eating; Neuropsychopharmaology?37?2593 5) Sabino?et al.?(2009),?The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking; Neuropsychopharmaology?34?1482

1-[2-(3,4-Dichlorophenyl)ethyl]-4-Methylpiperazine Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1-[2-(3,4-Dichlorophenyl)ethyl]-4-Methylpiperazine Dihydrochloride Suppliers

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206996-13-6, 1-[2-(3,4-Dichlorophenyl)ethyl]-4-Methylpiperazine DihydrochlorideRelated Search:

SKF 96365 HYDROCHLORIDE Astemizole Ginkgolide B Rapamycin

BD1063 (dhydrochloride)

BD 1063 (hydrochloride)

BD-1063 DHYDROCHLORIDE; BD 1063 DHYDROCHLORIDE

BD1063 HCl

1-(3,4-Dichlorophenethyl)-4-methylpiperazine dihydrochloride

Sigma Receptor,Inhibitor,inhibit,BD1063 dhydrochloride,BD-1063 dhydrochloride

206996-13-6

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