AMG-51

Product Name: AMG-51
CAS No.: 890019-63-3
Chemical Name: AMG-51
Synonyms: AMG-51;AMG-51 (KRC547);2-(4-fluoroanilino)-5-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-methylpyrimidin-4-one;5-[3-Fluoro-4-[[6-Methoxy-7-(3-Morpholinopropoxy)quinolin-4-yl]oxy]phenyl]-2-(4-fluorophenylaMino)-3-MethylpyriMidin-4(3H)-one;4(3H)-Pyrimidinone, 5-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-2-[(4-fluorophenyl)amino]-3-methyl-
CBNumber: CB42621126
Molecular Formula: C34H33F2N5O5
Formula Weight: 629.65
MOL File: 890019-63-3.mol

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AMG-51 Property

Boiling point:: 739.7±70.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
pka: 7.01±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Adipogen Life Sciences

Product number: SYN-1111-M001
Product name: AMG-51
Purity: ≥95%
Packaging: 1mg
Price: $205
Updated: 2021/12/16

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AMG-51 Chemical Properties,Usage,Production

Enzyme inhibitor

This protein kinase inhibitor (FW = 629.65 g/mol; CAS 890019-63-3; Solubility: 15 mM in DMSO), also known as 5-(3-fluoro-4-(6-methoxy-7- (3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-2-(4-fluorophenylamino)-3-methylpyrimidin-4(3H)-one, targets c-Met, or hepatocyte growth factor receptor (HGFR), a protein tyrosine kinase that plays a key role in several cellular processes and is overexpressed or mutated in different human cancers. AMG-51 shows the enzyme selectivity of c-Met with a (Ki = 4.9 nM), with off-targets, such as IGFR (Ki = 22nM), Ron or Recepteur d'Origine Nantais kinase (Ki = 28nM), and KDR (Ki = 139 nM).

AMG-51 Preparation Products And Raw materials

Raw materials

Preparation Products

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AMG-51 Suppliers

China 8 United Kingdom 1 United States 1 Global 10

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890019-63-3, AMG-51Related Search:

AMG-51

5-[3-Fluoro-4-[[6-Methoxy-7-(3-Morpholinopropoxy)quinolin-4-yl]oxy]phenyl]-2-(4-fluorophenylaMino)-3-MethylpyriMidin-4(3H)-one

2-(4-fluoroanilino)-5-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-methylpyrimidin-4-one

AMG-51 (KRC547)

4(3H)-Pyrimidinone, 5-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-2-[(4-fluorophenyl)amino]-3-methyl-

890019-63-3

C34H33F2N5O5