ChemicalBook > CAS DataBase List > AMG-51
AMG-51
- Product Name
- AMG-51
- CAS No.
- 890019-63-3
- Chemical Name
- AMG-51
- Synonyms
- AMG-51;AMG-51 (KRC547);2-(4-fluoroanilino)-5-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-methylpyrimidin-4-one;5-[3-Fluoro-4-[[6-Methoxy-7-(3-Morpholinopropoxy)quinolin-4-yl]oxy]phenyl]-2-(4-fluorophenylaMino)-3-MethylpyriMidin-4(3H)-one;4(3H)-Pyrimidinone, 5-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-2-[(4-fluorophenyl)amino]-3-methyl-
- CBNumber
- CB42621126
- Molecular Formula
- C34H33F2N5O5
- Formula Weight
- 629.65
- MOL File
- 890019-63-3.mol
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AMG-51 Property
- Boiling point:
- 739.7±70.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- pka
- 7.01±0.10(Predicted)
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N-Bromosuccinimide Price
Adipogen Life Sciences
- Product number
- SYN-1111-M001
- Product name
- AMG-51
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $205
- Updated
- 2021/12/16
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AMG-51 Chemical Properties,Usage,Production
Enzyme inhibitor
This protein kinase inhibitor (FW = 629.65 g/mol; CAS 890019-63-3; Solubility: 15 mM in DMSO), also known as 5-(3-fluoro-4-(6-methoxy-7- (3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-2-(4-fluorophenylamino)-3-methylpyrimidin-4(3H)-one, targets c-Met, or hepatocyte growth factor receptor (HGFR), a protein tyrosine kinase that plays a key role in several cellular processes and is overexpressed or mutated in different human cancers. AMG-51 shows the enzyme selectivity of c-Met with a (Ki = 4.9 nM), with off-targets, such as IGFR (Ki = 22nM), Ron or Recepteur d'Origine Nantais kinase (Ki = 28nM), and KDR (Ki = 139 nM).
AMG-51 Preparation Products And Raw materials
Raw materials
Preparation Products
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AMG-51 Suppliers
- Tel
- --
- Fax
- --
- info@creative-enzymes.com
- Country
- United States
- ProdList
- 6057
- Advantage
- 58