BenzeneMethanol, a-[[[2-(4-aMinophenyl)ethyl]aMino]Methyl]-, (aR)-

Product Name: BenzeneMethanol, a-[[[2-(4-aMinophenyl)ethyl]aMino]Methyl]-, (aR)-
CAS No.: 391901-45-4
Chemical Name: BenzeneMethanol, a-[[[2-(4-aMinophenyl)ethyl]aMino]Methyl]-, (aR)-
Synonyms: (R)-2-((4-AMinophenethyl)aMino)-1-phenylethanol;(R)-2-((4-aminophenethyl)amino)-1-phenylethan-1-ol;YM-208876;Mirabegron M16;MiraBegron impurity H;Mirabegron EP Impurity B;Mirabegron metabolite M16;Mirabegron Des-ATAA Impurity;2-(4-Nitophenyl) ethanamine hydrochloride;Mirabegron Impurity 20 (Mirabegron EP Impurity B)
CBNumber: CB42621166
Molecular Formula: C16H20N2O
Formula Weight: 256.34
MOL File: 391901-45-4.mol

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BenzeneMethanol, a-[[[2-(4-aMinophenyl)ethyl]aMino]Methyl]-, (aR)- Property

Melting point:: 97-100°C
Boiling point:: 447.9±24.0 °C(Predicted)
Density: 1.137±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly)
pka: 13.98±0.20(Predicted)
form: Solid
color: Off-White to Light Beige
InChI: InChI=1/C16H20N2O/c17-15-8-6-13(7-9-15)10-11-18-12-16(19)14-4-2-1-3-5-14/h1-9,16,18-19H,10-12,17H2/t16-/s3
InChIKey: TUAHDMSPHZSMQN-QEIABERDNA-N
SMILES: [C@@H](O)(C1=CC=CC=C1)CNCCC1=CC=C(N)C=C1 |&1:0,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A625970
Product name: (R)-2-((4-Aminophenethyl)amino)-1-phenylethanol
Packaging: 250mg
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: 9290BB
Product name: (R)-2-((4-Aminophenethyl)amino)-1-phenylethanol
Packaging: 250mg
Price: $68
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA75045
Product name: (aR)-a-[[[2-(4-Aminophenyl)ethyl]amino]methyl]-benzenemethanol
Packaging: 2g
Price: $72
Updated: 2021/12/16

AK Scientific

Product number: 9290BB
Product name: (R)-2-((4-Aminophenethyl)amino)-1-phenylethanol
Packaging: 25g
Price: $230
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA75045
Product name: (aR)-a-[[[2-(4-Aminophenyl)ethyl]amino]methyl]-benzenemethanol
Packaging: 25g
Price: $350
Updated: 2021/12/16

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BenzeneMethanol, a-[[[2-(4-aMinophenyl)ethyl]aMino]Methyl]-, (aR)- Chemical Properties,Usage,Production

Uses

(R)-2-((4-Aminophenethyl)amino)-1-phenylethanol is an intermediate in the synthesis of Mirabegron related compounds. irabegron is a potent bladder relaxant and reagent for diabetes remedy.

Synthesis

521284-21-9

391901-45-4

(R)-2-((4-nitrophenylethyl)amino)-1-phenylethanol hydrochloride (Compound I, 15 g, 0.0465 mol) was dissolved in 150 mL of methanol with stirring. Ammonium formate (14.6 g, 0.2325 mol) and 1.5 g of 10% palladium carbon catalyst were subsequently added. The reaction mixture was heated to 65 °C and kept at reflux for 5 hours. The reaction was monitored by thin layer chromatography (TLC, GF254 plate, unfolding agent ratio ethyl acetate:methanol = 5:1) until the fluorescent spots of compound I disappeared. Upon completion of the reaction, methanol was removed by concentration under reduced pressure, followed by the addition of water and ethyl acetate for extraction. The organic phase was evaporated under reduced pressure to remove ethyl acetate to give an off-white solid product (Compound II, 10.91 g) in 91.71% yield.

References

[1] Patent: CN105481705, 2016, A. Location in patent: Paragraph 0021; 0022; 0023
[2] Patent: WO2014/132270, 2014, A2. Location in patent: Page/Page column 19

BenzeneMethanol, a-[[[2-(4-aMinophenyl)ethyl]aMino]Methyl]-, (aR)- Preparation Products And Raw materials

Raw materials

Preparation Products

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BenzeneMethanol, a-[[[2-(4-aMinophenyl)ethyl]aMino]Methyl]-, (aR)- Suppliers

China 84 India 11 United Kingdom 1 United States 6 Global 102

Suzhou Uugene Biopharma Co., Ltd.

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ChemStrong Scientific Co.,Ltd

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View Lastest Price from BenzeneMethanol, a-[[[2-(4-aMinophenyl)ethyl]aMino]Methyl]-, (aR)- manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: BenzeneMethanol, a-[[[2-(4-aMinophenyl)ethyl]aMino]Methyl]-, (aR)- 391901-45-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: BenzeneMethanol, a-[[[2-(4-aMinophenyl)ethyl]aMino]Methyl]-, (aR)- 391901-45-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

Career Henan Chemical Co

Product: BenzeneMethanol, a-[[[2-(4-aMinophenyl)ethyl]aMino]Methyl]-, (aR)- 391901-45-4
Price: US $10.00/KG
Min. Order: 100G
Purity: 98
Supply Ability: 100KG
Release date: 2018-07-24

391901-45-4, BenzeneMethanol, a-[[[2-(4-aMinophenyl)ethyl]aMino]Methyl]-, (aR)-Related Search:

(R)-2-(2-aminothiazol-4-yl)-N-(2-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)acetamide Mirabegron Impurity Mirabegron Impurity 33 Mirabegron Impurity 38 2-[[2-2(2-Amino-4-thiazolyl)acetyl]amino]-4-thiazoleacetic Acid Mirabegron Impurity 8 HCl Mirabegron 2-Oxo Impurity Mirabegron iMpurity (alphaR)-alpha-[[[2-(4-Nitrophenyl)ethyl]amino]methyl]benzenemethanol Mirabegron Impurity 34

BenzeneMethanol, a-[[[2-(4-aMinophenyl)ethyl]aMino]Methyl]-, (aR)-

BenzeneMethanol, -[[[2-(4-aMinophenyl)ethyl]aMino]Methyl]-, (R)-

(alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]-benzenemethanol

(R)-2-((4-AMinophenethyl)aMino)-1-phenylethanol

(R)-2-((4-aminophenethyl)amino)-1-phenylethan-1-ol

(1 R)-2-[(4-aminophenethyl)amino]-1-phenyl-1-ethanol

MiraBegron impurity H

(aR)-a-[[[2-(4-Aminophenyl)ethyl]amino]methyl]-benzenemethanol

Mirabegron Des-ATAA Impurity

YM-208876

Mirabegron Impurity 6/ Mirabegron Intermediate?Impurity ((R)-2-((4-Aminophenethyl)amino)-1-phenylethanol)

Mirabegron metabolite M16

Mirabegron Impurity 6Q: What is Mirabegron Impurity 6 Q: What is the CAS Number of Mirabegron Impurity 6 Q: What is the storage condition of Mirabegron Impurity 6 Q: What are the applications of Mirabegron Impurity 6

Mirabegron M16

(1R)-2-[2-(4-aminophenyl)ethylamino]-1-phenylethanol

BenzeneMethanol,a-l[2-(4-aMinophenyl)ethyl]aMino]Methyl]-,(aR)-

2-(4-Nitophenyl) ethanamine hydrochloride

Benzenemethanol, α-[[[2-(4-aminophenyl)ethyl]amino]methyl]-, (αR)-

Mirabegron EP Impurity B

Mirabegron Impurity 20 (Mirabegron EP Impurity B)

(R)-[[[2-(4-aminophenyl)ethyl]amino]methyl]-benzylalcohol

391901-45-4

391901-45-5

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