5-PyriMidinecarboxylic acid, 4-aMino-2-(Methylthio)-
- Product Name
- 5-PyriMidinecarboxylic acid, 4-aMino-2-(Methylthio)-
- CAS No.
- 771-81-3
- Chemical Name
- 5-PyriMidinecarboxylic acid, 4-aMino-2-(Methylthio)-
- Synonyms
- 5-PyriMidinecarboxylic acid, 4-aMino-2-(Methylthio)-
- CBNumber
- CB42624617
- Molecular Formula
- C6H7N3O2S
- Formula Weight
- 185.2
- MOL File
- 771-81-3.mol
5-PyriMidinecarboxylic acid, 4-aMino-2-(Methylthio)- Property
- Melting point:
- 251-252 °C (decomp)
- Boiling point:
- 435.0±30.0 °C(Predicted)
- Density
- 1.53±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.29±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A898820
- Product name
- 4-Amino-2-(methylthio)pyrimidine-5-carboxylicacid
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- A898820
- Product name
- 4-Amino-2-(methylthio)pyrimidine-5-carboxylicacid
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- CHM0389802
- Product name
- 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.16
- Updated
- 2021/12/16
- Product number
- 2619AL
- Product name
- 4-Amino-2-(methylthio)pyrimidine-5-carboxylicacid
- Packaging
- 10g
- Price
- $1152
- Updated
- 2021/12/16
- Product number
- A334798
- Product name
- 4-Amino-2-(methylthio)pyrimidine-5-carboxylicacid
- Purity
- 98%
- Packaging
- 250mg
- Price
- $18
- Updated
- 2021/12/16
5-PyriMidinecarboxylic acid, 4-aMino-2-(Methylthio)- Chemical Properties,Usage,Production
Synthesis
776-53-4
771-81-3
The general procedure for the synthesis of 4-amino-2-(methylthio)pyrimidine-5-carboxylic acid from ethyl 2-(methylthio)-4-amino-pyrimidine-5-carboxylate was as follows: ethyl 4-amino-2-methylmercaptopyrimidine-5-carboxylate (1.5 g, 7 mmol) was suspended in a mixed methanol (10 mL) and water (5 mL) solution containing lithium hydroxide (340 mg, 14 mmol). solution, and the reaction was stirred at 60°C overnight. Upon completion of the reaction, the solid was collected by filtration and the filtrate was combined. The filtrate was concentrated under reduced pressure to remove the solvent. The residue was dissolved in water and the pH was adjusted with acetic acid to 5. The precipitated white solid was collected by filtration and dried under vacuum to give the target product (0.72 g, 55% yield). [0307] HPLC analysis (4 min gradient) showed retention time t R = 0.55 min; mass spectrometry analysis showed m/z 186.08 ([M + H]+).
References
[1] Patent: US2005/20590, 2005, A1. Location in patent: Page/Page column 27
[2] Journal of Organic Chemistry, 1956, vol. 21, p. 567,571
[3] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 4, p. 413 - 418
[4] Patent: WO2015/84936, 2015, A1. Location in patent: Page/Page column 93
5-PyriMidinecarboxylic acid, 4-aMino-2-(Methylthio)- Preparation Products And Raw materials
Raw materials
Preparation Products
5-PyriMidinecarboxylic acid, 4-aMino-2-(Methylthio)- Suppliers
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 025-58196018 800028039
- Fax
- 025-83453306
- sales@fartop.net
- Country
- China
- ProdList
- 2229
- Advantage
- 55
- Tel
- 18621020637 18621020637;
- sales@sunsynpharma.com
- Country
- China
- ProdList
- 288
- Advantage
- 55
- Tel
- 0523-86818997 18652728585
- sales@allyrise.com
- Country
- China
- ProdList
- 2966
- Advantage
- 60
- Tel
- 022-022-23301225 18202662021
- Fax
- 022-25541300
- Mingmingxuetsu@163.com
- Country
- China
- ProdList
- 313
- Advantage
- 56
- Tel
- 18957373295
- Fax
- -
- Country
- China
- ProdList
- 1580
- Advantage
- 58
- Tel
- 0513-0513-51005092 13390947892
- Fax
- 0513-51005092
- tashiyxy@163.com
- Country
- China
- ProdList
- 839
- Advantage
- 58
- Tel
- 0512-0512-52358471 17715136450
- Fax
- 05125235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 12127
- Advantage
- 58
- Tel
- 025-84112752 13805181430
- Fax
- +86-25-84846489
- 154301870@qq.com
- Country
- China
- ProdList
- 1000
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58