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ABC294640

Product Name
ABC294640
CAS No.
915385-81-8
Chemical Name
ABC294640
Synonyms
CS-802;ABC294640;ABC294640(Opaganib);Opaganib (ABC294640);3-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide;3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide;Tricyclo[3.3.1.13,7]decane-1-carboxamide, 3-(4-chlorophenyl)-N-(4-pyridinylmethyl);3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.1(3,7)]decane-1-carboxamide;ABC294640;ABC-294640;ABC 294640;3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE.;ABC294640; ABC-294640; ABC 294640; 3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE;OPAGANIB
CBNumber
CB42624930
Molecular Formula
C23H25ClN2O
Formula Weight
380.91
MOL File
915385-81-8.mol
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ABC294640 Property

Boiling point:
589.5±50.0 °C(Predicted)
Density 
1.273±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
≥38.1 mg/mL in DMSO; insoluble in H2O; ≥58.9 mg/mL in EtOH
form 
solid
pka
14.57±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Cayman Chemical
Product number
10587
Product name
ABC294640
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
10587
Product name
ABC294640
Purity
≥98%
Packaging
5mg
Price
$140
Updated
2024/03/01
Cayman Chemical
Product number
10587
Product name
ABC294640
Purity
≥98%
Packaging
10mg
Price
$235
Updated
2024/03/01
Cayman Chemical
Product number
10587
Product name
ABC294640
Purity
≥98%
Packaging
25mg
Price
$479
Updated
2024/03/01
Biosynth Carbosynth
Product number
BA162479
Product name
ABC 294640
Packaging
100mg
Price
$480
Updated
2021/12/16
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ABC294640 Chemical Properties,Usage,Production

Description

ABC294640 is an inhibitor of sphingosine kinase 2 (SPHK2; Ki = 9.8 μM). It inhibits SPHK2 (IC50 = 60 μM) without affecting SPHK1 activity up to 100 μM but does reduce SPHK1 isoform a (SPHK1a) protein levels in androgen-independent LNCaP (LNCaP-AI) cells via an SPHK1-indirect, proteasomal-dependent mechanism when used at concentrations ranging from 5 to 25 μM. ABC294640 is inactive against a panel of 20 lipid-regulated kinases at 50 μM. It decreases sphingosine-1-phosphate (S1P) production in MDA-MB-231 cells in a concentration-dependent manner. ABC294640 inhibits proliferation of a variety of cancer cells, including HepG2 liver, A-498 kidney, PANC-1 pancreas, and HT-29 colon cells (IC50s = 6, 12.2, 32.8, and 48.1 μM, respectively). It reduces actin filament polymerization in, and cell migration of, A-498 cells in a scratch assay. Oral administration of ABC294640 (35 and 100 mg/kg every other day) reduces tumor growth in a mouse syngeneic model of mammary adenocarcinoma. It also reduces colonic inflammation in mouse and rat models of Crohn’s disease induced by trinitrobenzene sulfonic acid (TNBS).

Uses

Opaganib is used in treating iatrogenic autoimmune colitis.

Definition

ChEBI: 3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)-1-adamantanecarboxamide is an organochlorine compound.

References

[1] french k j, zhuang y, maines l w, et al. pharmacology and antitumor activity of abc294640, a selective inhibitor of sphingosine kinase-2. journal of pharmacology and experimental therapeutics, 2010, 333(1): 129-139.
[2] antoon j w, white m d, meacham w d, et al. antiestrogenic effects of the novel sphingosine kinase-2 inhibitor abc294640. endocrinology, 2010, 151(11): 5124-5135.

ABC294640 Preparation Products And Raw materials

Raw materials

Preparation Products

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ABC294640 Suppliers

China 72 India 1 United States 11 Global 84
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Creative Enzymes
Tel
--
Fax
--
Email
info@creative-enzymes.com
Country
United States
ProdList
6057
Advantage
58
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View Lastest Price from ABC294640 manufacturers

Career Henan Chemical Co
Product
ABC294640 915385-81-8
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-12

915385-81-8, ABC294640Related Search:

Acetanilide

  • ABC294640
  • 3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.1(3,7)]decane-1-carboxamide
  • Tricyclo[3.3.1.13,7]decane-1-carboxamide, 3-(4-chlorophenyl)-N-(4-pyridinylmethyl)
  • ABC294640(Opaganib)
  • 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide
  • ABC294640; ABC-294640; ABC 294640; 3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE;OPAGANIB
  • CS-802
  • ABC294640;ABC-294640;ABC 294640;3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE.
  • Opaganib (ABC294640)
  • 3-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide
  • 915385-81-8