DINOPROST ETHANOLAMIDE
- Product Name
- DINOPROST ETHANOLAMIDE
- CAS No.
- 353787-70-9
- Chemical Name
- DINOPROST ETHANOLAMIDE
- Synonyms
- PGF2ALPHA-EA;DINOPROST ETHANOLAMIDE;ProstaglandinF2α ethanolamide;PROSTAGLANDIN F2A ETHANOLAMIDE;Prostaglandin F2α Ethanolamide;PROSTAGLANDIN F2ALPHA ETHANOLAMIDE;Prostaglandin F2 Ethanolamide MaxSpecStandard;Prostaglandin F2α Ethanolamide MaxSpec? Standard;Prostaglandin F2α Ethanolamide Lipid Maps MS Standard;Prostaglandin F2α Ethanolamide Lipid Maps? MS Standard
- CBNumber
- CB4262538
- Molecular Formula
- C22H39NO5
- Formula Weight
- 397.55
- MOL File
- 353787-70-9.mol
DINOPROST ETHANOLAMIDE Property
- Flash point:
- 14 °C
- storage temp.
- −20°C
- solubility
- DMF: Miscible; DMSO: 10 mg/ml; Ethanol: Miscible; PBS (pH 7.2): 10 mg/ml
Safety
- Hazard Codes
- F,Xi
- Risk Statements
- 11-36/37/38
- Safety Statements
- 7-16-26-36
- RIDADR
- UN 1170 3/PG 2
- WGK Germany
- 1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P6738
- Product name
- Prostaglandin F2α ethanolamide
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $571
- Updated
- 2023/06/20
- Product number
- 16013
- Product name
- Prostaglandin F2α Ethanolamide
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $71
- Updated
- 2024/03/01
- Product number
- 16013
- Product name
- Prostaglandin F2α Ethanolamide
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $313
- Updated
- 2024/03/01
- Product number
- 16013
- Product name
- Prostaglandin F2α Ethanolamide
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $554
- Updated
- 2024/03/01
- Product number
- 10007222
- Product name
- Prostaglandin F2α Ethanolamide MaxSpec? Standard
- Purity
- ≥95%
- Packaging
- 100μg
- Price
- $112
- Updated
- 2023/06/20
DINOPROST ETHANOLAMIDE Chemical Properties,Usage,Production
Description
Prostaglandin F2α ethanolamide (PGF2α-EA) is produced by COX-2 metabolism of the endogenous cannabinoid, arachidonoyl ethanolamide (AEA), found in brain, liver, and other mammalian tissues. AEA can be metabolized directly by the sequential action of COX-2 and specific PG synthases to produce ethanolamide congeners of the classical PGs. PGF2α-EA has also been reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of living mice. PGF2α-EA is a potent dilator (EC50 = 58 nM) of the cat iris sphincter, which is a model system for testing potential intraocular hypotensive agents.
Uses
Prostaglandin F2α ethanolamide (Prostamide F2α) is an ethanolamide-like G protein-coupled receptor. Prostaglandin F2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord[1][2][3].
Definition
ChEBI: Prostaglandin F2alpha 1-ethanolamide is an N-acylethanolamine compound formed by a condensation of prostaglandin F2alpha and ethanolamine. It is a N-acylethanolamine and a prostaglandins Falpha. It is functionally related to a prostaglandin F2alpha.
Biological Activity
The end-product of the reaction of arachidonyl ethanolamide (AEA), an endogenous ligand for brain cannabinoid receptor, with COX-2.
References
[1] Richie-Jannetta R, et al. Structural determinants for calcium mobilization by prostaglandin E2 and prostaglandin F2alpha glyceryl esters in RAW 264.7 cells and H1819 cells. Prostaglandins Other Lipid Mediat. 2010 Jun;92(1-4):19-24. DOI:10.1016/j.prostaglandins.2010.01.003
[2] Woodward DF, et al. Recent progress in prostaglandin F2α ethanolamide (prostamide F2α) research and therapeutics. Pharmacol Rev. 2013 Jul 26;65(4):1135-47. DOI:10.1124/pr.112.007088
[3] McCracken J A, et al. Prostaglandin F2α identified as a luteolytic hormone in sheep[J]. Nature New Biology, 1972, 238(83): 129-134.
DINOPROST ETHANOLAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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