4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)-

Product Name: 4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)-
CAS No.: 805245-41-4
Chemical Name: 4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)-
Synonyms: X-3117 int;RX-3117 int;(3R,4R,6aR)-tert-butyl-(5-fluoro-2,2-dimethyl-6-trityloxymet;4H-Cyclopenta-1,3-dioxole,4-[[(1,1-diMethylethyl)diphenylsil...;(3R,4R,6aR)-tert-butyl-(5-fluoro-2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yloxy)-diphenyl-silane;tert-butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane;((3aR,4R,6aR)-5-fluoro-4,6a-dihydro-2,2-dimethyl-6-((trityloxy)methyl)-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)(tert-butyl)diphenylsilane;tert-Butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane;(3aR,4R,6aR)-4-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-dimethyl-6-[(triphenylmethoxy)methyl]-4H-cyclopenta-1,3-dioxole;4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)-
CBNumber: CB42627067
Molecular Formula: C44H45FO4Si
Formula Weight: 684.91
MOL File: 805245-41-4.mol

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4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)- Property

Boiling point:: 681.5±55.0 °C(Predicted)
Density: 1.18±0.1 g/cm3(Predicted)
storage temp.: 2-8°C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 3795EA
Product name: CID86268842
Packaging: 100mg
Price: $212
Updated: 2021/12/16

Ambeed

Product number: A209064
Product name: tert-Butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane
Purity: 95+%
Packaging: 1g
Price: $267
Updated: 2021/12/16

Crysdot

Product number: CD42000216
Product name: tert-Butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane
Purity: 95+%
Packaging: 250mg
Price: $269
Updated: 2021/12/16

Alichem

Product number: 805245414
Product name: tert-Butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane
Packaging: 250mg
Price: $291.04
Updated: 2021/12/16

Chemenu

Product number: CM137845
Product name: tert-butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane
Purity: 95%
Packaging: 1g
Price: $636
Updated: 2021/12/16

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4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)- Chemical Properties,Usage,Production

Synthesis

805245-40-3

805245-41-4

The general procedure for the synthesis of (((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((tolylsulfonyloxy)methyl)-4,6a-dihydro-3aH-cyclopentadieno[d][1,3]dioxol-4-yl)oxy)diphenylsilanes from the compound (CAS: 805245-40-3) was carried out as follows: under the protection of nitrogen ( 3R,4R,6aR)-tert-butyl-(5-fluoro-2,2-dimethyl-6-tritylmethoxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxolen-4- yloxy)diphenylsilane (10, 11.66 g, 14.71 mmol) and N-fluorobenzenesulfonimide (5.566 g, 17.65 mmol) were dissolved in anhydrous tetrahydrofuran (100 mL) and cooled to -78 °C. n-Butyllithium (27.6 mL, 44.13 mmol, 1.6 M hexane solution) was slowly added and the reaction mixture was stirred for 1 hour at a maintained temperature of -78 °C. Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride solution and subsequently extracted with ethyl acetate. The organic layers were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure. The crude product was purified by fast silica gel column chromatography (eluent: hexane/ethyl acetate = 6:1) to afford the target compound 11 (7.35 g, 73% yield) as a white solid.1H NMR (400 MHz, CDCl3) δ 7.81-7.17 (m, 25H), 4.94 (t, J=7.2 Hz, 1H), 4.35 (m, 1H), 4.25 (m, 1H), 4.25 (m, 1H). 4.25 (m, 1H), 3.89 (t, J=12.0 Hz, 1H), 3.77 (t, J=12.0 Hz, 1H), 1.42 (s, 3H), 1.38 (s, 3H), 1.08 (s, 9H).

References

[1] Patent: US2005/222185, 2005, A1. Location in patent: Page/Page column 7
[2] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 22, p. 5641 - 5644
[3] Nucleosides, Nucleotides and Nucleic Acids, 2005, vol. 24, # 5-7, p. 707 - 708
[4] Patent: WO2014/145807, 2014, A1. Location in patent: Page/Page column 9; 26; 27
[5] Patent: WO2014/145807, 2014, A1

4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)- Preparation Products And Raw materials

Raw materials

Preparation Products

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4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)- Suppliers

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805245-41-4, 4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)-Related Search:

2-tirfluoromethylpyridine DYES INTERMEDIATES

4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)-

tert-Butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane

RX-3117 int

(3aR,4R,6aR)-4-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-dimethyl-6-[(triphenylmethoxy)methyl]-4H-cyclopenta-1,3-dioxole

(3R,4R,6aR)-tert-butyl-(5-fluoro-2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yloxy)-diphenyl-silane

X-3117 int

((3aR,4R,6aR)-5-fluoro-4,6a-dihydro-2,2-dimethyl-6-((trityloxy)methyl)-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)(tert-butyl)diphenylsilane

tert-butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane

4H-Cyclopenta-1,3-dioxole,4-[[(1,1-diMethylethyl)diphenylsil...

(3R,4R,6aR)-tert-butyl-(5-fluoro-2,2-dimethyl-6-trityloxymet

805245-41-4

C44H45FO4Si