BIX-02565

ChemicalBook > CAS DataBase List > BIX-02565

Product Name: BIX-02565
CAS No.: 1311367-27-7
Chemical Name: BIX-02565
Synonyms: CS-2569;BIX-02565;BIX-02565;BIX02565;Inhibitor,BIX02565,BIX-02565,Ribosomal S6 Kinase (RSK),S6K,BIX 02565,inhibit;(5R)-N-{1-[3-(dimethylamino)propyl]-1H-1,3-benzodiazol-2-yl}-5-methyl-1-oxo-1H,2H,3H,4H,5H-[1,4]diazepino[1,2-a]indole-8-carboxamide;(5R)-N-[1-[3-(Dimethylamino)propyl]-1H-benzimidazol-2-yl]-2,3,4,5-tetrahydro-5-methyl-1-oxo-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide;(R)-N-(1-(3-(Dimethylamino)propyl)-1H-benzo[d]imidazol-2-yl)-5-methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide;1H-[1,4]Diazepino[1,2-a]indole-8-carboxamide, N-[1-[3-(dimethylamino)propyl]-1H-benzimidazol-2-yl]-2,3,4,5-tetrahydro-5-methyl-1-oxo-, (5R)-
CBNumber: CB42627603
Molecular Formula: C26H30N6O2
Formula Weight: 458.56
MOL File: 1311367-27-7.mol

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BIX-02565 Property

Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥22.95 mg/mL in DMSO; insoluble in H2O; ≥3.17 mg/mL in EtOH with gentle warming and ultrasonic
form: Powder
pka: 12.30±0.40(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19183
Product name: BIX 02565
Purity: ≥98%
Packaging: 500μg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 19183
Product name: BIX 02565
Purity: ≥98%
Packaging: 1mg
Price: $66
Updated: 2024/03/01

Cayman Chemical

Product number: 19183
Product name: BIX 02565
Purity: ≥98%
Packaging: 5mg
Price: $223
Updated: 2024/03/01

ChemScene

Product number: CS-1659
Product name: BIX02565
Purity: 99.33%
Packaging: 5mg
Price: $228
Updated: 2021/12/16

ApexBio Technology

Product number: B1295
Product name: BIX02565
Packaging: 5mg
Price: $238
Updated: 2021/12/16

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BIX-02565 Chemical Properties,Usage,Production

Biological Activity

bix 02565 is a novel inhibitor of ribosomal s6 kinase 2 with ic50 value of 1 nm [1].ribosomal s6 kinase (rsk) is a na/h exchanger (nhe) -activating factor and is important for ph maintenance during the early phase of cellular stress. while, nhe activation leads to ca2+ overload and cardiac hypertrophy over longer periods [2].bix 02565 is a novel rsk2 inhibitor. also, bix 02565 inhibited adrenergic ɑ1a-, ɑ1b-, ɑ1d-, ɑ2a-, β2- and imidazoline i2 receptors with ic50 values ranging from 0.052 to 1.820 μm. these receptors played important roles in the regulation of vascular tone and cardiac function [2]. also, bix 02565 inhibited lrrk2 and prkd1 with ic50 values of 16 and 35 nm [1].in the rat cv screen, bix 02565 (1, 3 and 10 mg/kg) significantly decreased heart rate (-93 +13 beats/min) and mean arterial pressure (map: to -65 +6 mm hg below baseline). in telemetry-instrumented rats, bix 02565 (30, 100 and 300 mg/kg for 4 days) reduced map (to -39 + 4 mm hg) in a concentration-dependent way [2].

References

[1]. kirrane tm, boyer sj, burke j, et al. indole rsk inhibitors. part 2: optimization of cell potency and kinase selectivity. bioorg med chem lett, 2012, 22(1): 738-742.
[2]. fryer rm, muthukumarana a, chen rr, et al. mitigation of off-target adrenergic binding and effects on cardiovascular function in the discovery of novel ribosomal s6 kinase 2 inhibitors. j pharmacol exp ther, 2012, 340(3): 492-500.

BIX-02565 Preparation Products And Raw materials

Raw materials

Preparation Products

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1311367-27-7, BIX-02565Related Search:

BIX-02565

(5R)-N-[1-[3-(Dimethylamino)propyl]-1H-benzimidazol-2-yl]-2,3,4,5-tetrahydro-5-methyl-1-oxo-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide

CS-2569

BIX-02565;BIX02565

Inhibitor,BIX02565,BIX-02565,Ribosomal S6 Kinase (RSK),S6K,BIX 02565,inhibit

1H-[1,4]Diazepino[1,2-a]indole-8-carboxamide, N-[1-[3-(dimethylamino)propyl]-1H-benzimidazol-2-yl]-2,3,4,5-tetrahydro-5-methyl-1-oxo-, (5R)-

(R)-N-(1-(3-(Dimethylamino)propyl)-1H-benzo[d]imidazol-2-yl)-5-methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide

(5R)-N-{1-[3-(dimethylamino)propyl]-1H-1,3-benzodiazol-2-yl}-5-methyl-1-oxo-1H,2H,3H,4H,5H-[1,4]diazepino[1,2-a]indole-8-carboxamide

1311367-27-7