EP-1013

Product Name: EP-1013
CAS No.: 223568-55-6
Chemical Name: EP-1013
Synonyms: F 1013;EP-1013;EP1013,EP-1013;EP1013 (F1013);Z-VD-FMK (mixture of isomers);(3S)-5-Fluoro-3-[[(2S)-3-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]amino]-4-oxopentanoic acid;Pentanoic acid, 5-fluoro-3-[[(2S)-3-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]amino]-4-oxo-, (3S)-
CBNumber: CB42627805
Molecular Formula: C18H23FN2O6
Formula Weight: 382.38
MOL File: 223568-55-6.mol

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EP-1013 Property

Boiling point:: 639.8±55.0 °C(Predicted)
Density: 1.258±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 60 mg/mL (156.91 mM)
pka: 3.92±0.19(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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EP-1013 Chemical Properties,Usage,Production

Uses

EP1013 (F1013) is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes[1].

in vivo

EP1013 (1, 3, 10 mg/kg) significantly improves marginal islet mass function. Two animals in the 10 mg/kg EP1013 treatment group exhibit primary islet graft nonfunction, but the diabetes reversal rate for this group is not significantly different from the 3 mg/kg EP1013, 1 mg/kg EP1013, or 10 mg/kg zVAD groups. EP1013 therapy enhances functional syngeneic islet mass and promotes longevity of islet graft function^[1].

IC 50

Caspase

References

[1] Emamaullee JA, et al. The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice. Diabetes. 2008 Jun;57(6):1556-66. DOI:10.2337/db07-1452

EP-1013 Preparation Products And Raw materials

Raw materials

Preparation Products

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EP-1013 Suppliers

China 22 United States 5 USA 1 Global 28

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
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TargetMol Chemicals Inc.

Tel: +17819995354
Email: marketing@targetmol.com
Country: United States
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TargetMol Chemicals Inc.

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MedChemExpress

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Combi-Blocks Inc.

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223568-55-6, EP-1013Related Search:

EP-1013

(3S)-5-Fluoro-3-[[(2S)-3-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]amino]-4-oxopentanoic acid

F 1013

Z-VD-FMK (mixture of isomers)

Pentanoic acid, 5-fluoro-3-[[(2S)-3-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]amino]-4-oxo-, (3S)-

EP1013 (F1013)

EP1013,EP-1013

223568-55-6