ChemicalBook > CAS DataBase List > ST 2825

ST 2825

Product Name
ST 2825
CAS No.
894787-30-5
Chemical Name
ST 2825
Synonyms
ST 2825;ST 2825;ST2825;(2R,4'R,8a'R)-1-(2-(4-(2-(2,4-Dichlorophenoxy)acetamido)phenyl)acetyl)-6'-oxotetrahydro-2'H,6'H-spiro[pyrrolidine-2,7'-pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide;(2R,4'R,8a'R)-1-(2-(4-(2-(2,4-Dichlorophenoxy)acetamido)phenyl)acetyl)-6'-oxotetrahydro-2'H,6'H-spiro[pyrrolidine-2,7'-pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide;(2R,4'R,8'aR)-1-[2-[4-[[2-(2,4-Dichlorophenoxy)acetyl]amino]phenyl]acetyl]tetrahydro-6'-oxospiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide;Spiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide, 1-[2-[4-[[2-(2,4-dichlorophenoxy)acetyl]amino]phenyl]acetyl]tetrahydro-6'-oxo-, (2R,4'R,8'aR)-
CBNumber
CB42628433
Molecular Formula
C27H28Cl2N4O5S
Formula Weight
591.51
MOL File
894787-30-5.mol
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ST 2825 Property

Boiling point:
939.0±65.0 °C(Predicted)
Density 
1.51±0.1 g/cm3(Predicted)
solubility 
Soluble in DMSO
form 
solid
pka
12.86±0.70(Predicted)
color 
White to off-white
InChIKey
HBLHLJXFIPCEMW-ZJSFPPFMSA-N
SMILES
N1(C(CC2=CC=C(NC(COC3=CC=C(Cl)C=C3Cl)=O)C=C2)=O)CCC[C@]21C(=O)N1[C@@H](C(N)=O)CCS[C@]1([H])C2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0797
Product name
ST2825
Purity
99.86%
Packaging
1mg
Price
$426
Updated
2021/12/16
ApexBio Technology
Product number
A3840
Product name
ST2825
Packaging
1mg
Price
$520
Updated
2021/12/16
ChemScene
Product number
CS-0797
Product name
ST2825
Purity
99.86%
Packaging
5mg
Price
$1464
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611397
Product name
ST-2825
Packaging
5mg
Price
$1470.5
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611397
Product name
ST-2825
Packaging
10mg
Price
$2223.6
Updated
2021/12/16
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ST 2825 Chemical Properties,Usage,Production

Biological Activity

st 2825 is a specific inhibitor of myd88 dimerization [1].st 2825 is a synthetic compound which mimics the structure of the heptapeptide in the bb-loop of the myd88-tir domain and interferes the homodimerization of myd88. st 2825 was proved to specifically inhibit the homodimerization of myd88 tir domains without affecting the homodimerization of death domains. in hek293t cells transfected with flag-myd88 and myc-myd88, st 2825 inhibited the interaction of the two myd88 by 80% at the concentration of 10 μm. this inhibition resulted in the subsequent interference of the irak1 and irak4 recruitment. besides that, administration of st 2825 significantly inhibited the il-6 production stimulated by il-1β at doses of 100 and 200 mg/kg in mice. furthermore, 8 μm st 2825 completely blocked the tlr9-induced b cell proliferation. st2825 also suppressed the generation of plasma cells induced by cpg dose-dependently [1].

target

MyD88

References

[1] loiarro m, capolunghi f, fantò n, et al. pivotal advance: inhibition of myd88 dimerization and recruitment of irak1 and irak4 by a novel peptidomimetic compound. journal of leukocyte biology, 2007, 82(4): 801-810.

ST 2825 Preparation Products And Raw materials

Raw materials

Preparation Products

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ST 2825 Suppliers

China 41 United States 8 Global 49
Haoyuan Chemexpress Co., Ltd.
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894787-30-5, ST 2825Related Search:

N,N-DIETHYLBENZAMIDE

  • (2R,4'R,8'aR)-1-[2-[4-[[2-(2,4-Dichlorophenoxy)acetyl]amino]phenyl]acetyl]tetrahydro-6'-oxospiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide
  • ST 2825;ST2825
  • ST 2825
  • Spiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide, 1-[2-[4-[[2-(2,4-dichlorophenoxy)acetyl]amino]phenyl]acetyl]tetrahydro-6'-oxo-, (2R,4'R,8'aR)-
  • (2R,4'R,8a'R)-1-(2-(4-(2-(2,4-Dichlorophenoxy)acetamido)phenyl)acetyl)-6'-oxotetrahydro-2'H,6'H-spiro[pyrrolidine-2,7'-pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide
  • (2R,4'R,8a'R)-1-(2-(4-(2-(2,4-Dichlorophenoxy)acetamido)phenyl)acetyl)-6'-oxotetrahydro-2'H,6'H-spiro[pyrrolidine-2,7'-pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide
  • 894787-30-5
  • C27H28Cl2N4O5S