Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)-

Product Name: Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)-
CAS No.: 540769-28-6
Chemical Name: Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)-
Synonyms: Palosuran;ACT 058362;PALOSURAN,, >98%;ACT058362;ACT-058362;Palosuran (ACT058362);ACT 058362; PALOSURAN,;ACT 058362; PALOSURAN,, >98%;1-[2-(4-Benzyl-4-hydroxypiperidin-1-yl)ethyl]-3-(2-methylquinolin-4-yl)urea;N-[2-[4-Hydroxy-4-(phenylmethyl)-1-piperidinyl]ethyl]-N'-(2-methyl-4-quinolinyl)urea;Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)-
CBNumber: CB42628509
Molecular Formula: C25H30N4O2
Formula Weight: 418.53
MOL File: 540769-28-6.mol

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Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)- Property

Boiling point:: 612.9±55.0 °C(Predicted)
Density: 1.235±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 0.5 mg/ml
form: A crystalline solid
pka: 12.95±0.43(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23460
Product name: Palosuran
Packaging: 1mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 23460
Product name: Palosuran
Packaging: 10mg
Price: $864
Updated: 2024/03/01

Cayman Chemical

Product number: 23460
Product name: Palosuran
Packaging: 5mg
Price: $459
Updated: 2024/03/01

ApexBio Technology

Product number: B1304
Product name: Palosuran
Packaging: 25mg
Price: $523
Updated: 2021/12/16

ApexBio Technology

Product number: B1304
Product name: Palosuran
Packaging: 50mg
Price: $855
Updated: 2021/12/16

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Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)- Chemical Properties,Usage,Production

Description

Palosuran is an antagonist of the urotensin II receptor (UTR; IC₅₀s = 3.6 and 1,475 nM for CHO cell membranes expressing human and rat recombinant receptors, respectively). It inhibits contraction of isolated rat aortic rings induced by urotensin II (Item Nos. 24711 | 24753) in a concentration-dependent manner. Palosuran (300 mg/kg twice per day) reduces plasma endothelin-1 , urotensin II, and TGF-β1 levels, as well as the main pulmonary arterial pressure and right ventricular hypertrophy index in a rat model of pulmonary arterial hypertension (PAH) induced by monocrotaline . Palosuran (300 mg/kg per day) reduces serum glucose, cholesterol, and triglyceride levels and increases survival in a rat model of diabetes induced by streptozotocin (STZ; ). It also decreases albuminuria and global kidney lesion scores in STZ-induced diabetic rats.

Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)- Suppliers

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View Lastest Price from Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)- manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Palosuran 540769-28-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Palosuran 540769-28-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

540769-28-6, Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)-Related Search:

Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)-

Palosuran

ACT 058362

ACT 058362; PALOSURAN,

1-[2-(4-Benzyl-4-hydroxypiperidin-1-yl)ethyl]-3-(2-methylquinolin-4-yl)urea

N-[2-[4-Hydroxy-4-(phenylmethyl)-1-piperidinyl]ethyl]-N'-(2-methyl-4-quinolinyl)urea

ACT058362;ACT-058362

ACT 058362; PALOSURAN,, >98%

PALOSURAN,, >98%

Palosuran (ACT058362)

ACT058362,urotensin,Palosuran,Inhibitor,ischemia,diabetic,UT receptor,reperfusion,Urotensin Receptor,ACT 058362,renal,inhibit,pancreatic

540769-28-6

Inhibitors