CZC-25146 hydrochloride

Product Name: CZC-25146 hydrochloride
CAS No.: 1330003-04-7
Chemical Name: CZC-25146 hydrochloride
Synonyms: CS-1074;CS-1206;CZC-25146.HCl;CZC-25146 hydrochL;CZC-25146 hydrochloride;CZC-25146 hydrochloride >=98% (HPLC);CZC-25146; CZC 25146; CZC25146;CZC25146 HYDROCHLORIDE;CZC 25146 HYDROCHLORIDE;N-[2-[[5-Fluoro-2-[[2-Methoxy-4-(4-Morpholinyl)phenyl]aMino]-4-pyriMidinyl]aMino]phenyl]-MethanesulfonaMide hydrochloride;CZC-25146.HCL;N-[2-[[5-FLUORO-2-[[2-METHOXY-4-(4-MORPHOLINYL)PHENYL]AMINO]-4-PYRIMIDINYL]AMINO]PHENYL]-METHANESULFONAMIDE HYDROCHLORIDE;Leucine-rich repeat kinase 2,CZC25146,neurons,LRRK2 G2019S,CZC 25146,Inhibitor,liver diseases,inflammatory,Parkinson's disease,LRRK2,inhibit,CZC-25146,CZC 25146 hydrochloride,CZC25146 hydrochloride
CBNumber: CB42630076
Molecular Formula: C22H26ClFN6O4S
Formula Weight: 524.9960432
MOL File: 1330003-04-7.mol

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CZC-25146 hydrochloride Property

storage temp.: 2-8°C
solubility: DMSO: >15mg/mL (warmed)
form: powder
color: white to beige

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Safety

Hazard Codes: T,Xi
Risk Statements: 25-36
Safety Statements: 26-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Crysdot

Product number: CD31003869
Product name: CZC-25146 hydrochloride
Purity: 98+%
Packaging: 5mg
Price: $79
Updated: 2021/12/16

Crysdot

Product number: CD31003869
Product name: CZC-25146 hydrochloride
Purity: 98+%
Packaging: 50mg
Price: $603
Updated: 2021/12/16

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CZC-25146 hydrochloride Chemical Properties,Usage,Production

Uses

N-(2-(2-(2-Methoxy-4-morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)methanesulfonamide is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons’s disease, and is ATP-competitive.

in vivo

CZC-25146 (1 mg/kg for i.v.; 5 mg/kg for p.o.; single dosage) exhibits relatively good pharmacokinetic properties and an extensive distribution throughout animal body following intravenous injection into mice^[1].
CZC-25146 (250 mg/kg; p.o.; 14 days) reduces the ATZ polymer levels in over expressing human polymeric ATZ mice^[3].

Animal Model:

Male CD-1 mice^[1]

Dosage:

1 mg/kg for i.v.; 5 mg/kg for p.o.

Administration:

i.v. and p.o.; single dosage

Result:

Pharmacokinetic Parameters of CZC-25146 in male CD-1 mice^[1].

	i.v. (1 mg/kg)	p.o. (5 mg/kg)
CL (L/h/kg)	2.3
V_ss (L/kg)	5.4
t_1/2 (h)	1.6	1
t_max (h)	0	0.25
C_max (ng/mL)	154	1357
AUC_last (ng/mL·h)	419	2878
AUC_inf (ng/mL·h)	434	2894
F (%)		133

Animal Model:	Genetically modified male mice (6 weeks; over expressing human polymeric ATZ)^[3]
Dosage:	250 mg/kg
Administration:	p.o.; 14 days
Result:	Dramatically and reproducibly reduced the ATZ polymer levels with an overall reduction from 60% in the control group to 37%

CZC-25146 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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CZC-25146 hydrochloride Suppliers

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1330003-04-7, CZC-25146 hydrochlorideRelated Search:

CZC-25146 hydrochloride

CZC-25146.HCl

CZC-25146.HCL;N-[2-[[5-FLUORO-2-[[2-METHOXY-4-(4-MORPHOLINYL)PHENYL]AMINO]-4-PYRIMIDINYL]AMINO]PHENYL]-METHANESULFONAMIDE HYDROCHLORIDE

N-[2-[[5-Fluoro-2-[[2-Methoxy-4-(4-Morpholinyl)phenyl]aMino]-4-pyriMidinyl]aMino]phenyl]-MethanesulfonaMide hydrochloride

CS-1206

CS-1074

CZC-25146; CZC 25146; CZC25146;CZC25146 HYDROCHLORIDE;CZC 25146 HYDROCHLORIDE

CZC-25146 hydrochL

CZC-25146 hydrochloride >=98% (HPLC)

Leucine-rich repeat kinase 2,CZC25146,neurons,LRRK2 G2019S,CZC 25146,Inhibitor,liver diseases,inflammatory,Parkinson's disease,LRRK2,inhibit,CZC-25146,CZC 25146 hydrochloride,CZC25146 hydrochloride

1330003-04-7