tert-Butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate
- Product Name
- tert-Butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate
- CAS No.
- 333954-86-2
- Chemical Name
- tert-Butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate
- Synonyms
- 4-(1-BOC-Piperidin-4-yloxy)benzonitrile;tert-Butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate;4-[(1-(tert-Butoxycarbonyl)-4-piperidinyl)oxy]benzonitrile;4-(4-cyano phenoxy)piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-(4-cyanophenoxy)-, 1,1-dimethylethyl ester
- CBNumber
- CB42630733
- Molecular Formula
- C17H22N2O3
- Formula Weight
- 302.37
- MOL File
- 333954-86-2.mol
tert-Butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate Property
- Boiling point:
- 443.9±35.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -2.47±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- B810103
- Product name
- tert-Butyl4-(4-Cyanophenoxy)piperidine-1-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB143557
- Product name
- tert-Butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB143557
- Product name
- tert-Butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate
- Packaging
- 1g
- Price
- $131
- Updated
- 2021/12/16
- Product number
- FB143557
- Product name
- tert-Butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate
- Packaging
- 2g
- Price
- $228
- Updated
- 2021/12/16
- Product number
- 126561
- Product name
- tert-Butyl4-(4-cyanophenoxy)-piperidine-1-carboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $306
- Updated
- 2021/12/16
tert-Butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate Chemical Properties,Usage,Production
Synthesis
767-00-0
118811-07-7
333954-86-2
Step (i): preparation of tert-butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate 4-Hydroxybenzonitrile (15 g, 0.126 mol), potassium carbonate (28.89 g, 0.208 mol) and tert-butyl 4-(toluene-4-sulfonyloxy)piperidine-1-carboxylate (57.62 g, 0.162 mol) were dissolved in dimethylformamide (150 mL), and the reaction was stirred at 100 °C. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was quenched by pouring into water (400 mL) and extracted with ethyl acetate (3 x 300 mL). The combined organic layers were washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography with the eluent ethyl acetate:hexane (1:9) to afford 21.25 g (yield: 55.8%) of the title compound. 1H NMR (δ ppm): 1.47 (9H, s), 1.74-1.80 (2H, m), 1.91-1.96 (2H, m), 3.33-3.40 (2H, m), 3.66-3.72 (2H, m), 4.53-4.57 (1H, m), 6.94-6.96 (2H, d, J = 8.78 Hz), 7.57-7.59 (2H, d, J = 8.76 Hz). Mass spectrum (m/z): 303.4 (M + H)+.
References
[1] Patent: WO2012/114348, 2012, A1. Location in patent: Page/Page column 11
[2] Patent: US2014/135304, 2014, A1. Location in patent: Paragraph 0115-0117
tert-Butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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