2-chloro-3-cyclopropylpyridine
- Product Name
- 2-chloro-3-cyclopropylpyridine
- CAS No.
- 865664-04-6
- Chemical Name
- 2-chloro-3-cyclopropylpyridine
- Synonyms
- 2-chloro-3-cyclopropylpyridine;Pyridine, 2-chloro-3-cyclopropyl-
- CBNumber
- CB42631295
- Molecular Formula
- C8H8ClN
- Formula Weight
- 153.61
- MOL File
- 865664-04-6.mol
2-chloro-3-cyclopropylpyridine Property
- Boiling point:
- 219.4±28.0 °C(Predicted)
- Density
- 1.252±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.79±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- HCH0363434
- Product name
- 2-CHLORO-3-CYCLOPROPYLPYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.16
- Updated
- 2021/12/16
- Product number
- 8034DA
- Product name
- 2-Chloro-3-cyclopropylpyridine
- Packaging
- 5g
- Price
- $1446
- Updated
- 2021/12/16
- Product number
- AA00IE1R
- Product name
- 2-Chloro-3-cyclopropylpyridine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1502
- Updated
- 2021/12/16
- Product number
- CD11041272
- Product name
- 2-Chloro-3-cyclopropylpyridine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $941
- Updated
- 2021/12/16
- Product number
- 6573960
- Product name
- 2-Chloro-3-cyclopropylpyridine
- Purity
- 95%
- Packaging
- 5G
- Price
- $950
- Updated
- 2021/12/16
2-chloro-3-cyclopropylpyridine Chemical Properties,Usage,Production
Synthesis
78607-36-0
411235-57-9
865664-04-6
GENERAL STEPS: 2-chloro-3-iodopyridine (2.39 g, 9.98 mmol), cyclopropylboronic acid (860 mg, 10 mmol) and potassium carbonate (4.14 g, 30.0 mmol) were suspended in 1,4-dioxane (50 mL) under nitrogen protection. Tetrakis(triphenylphosphine)palladium(0) (1.16 g, 1.00 mmol) was subsequently added as a catalyst. The reaction mixture was stirred vigorously in an oil bath at 120°C for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate (50 mL) and filtered through a diatomaceous earth pad to remove insoluble impurities. The filtrate was concentrated under reduced pressure and the crude product obtained was purified by silica gel column chromatography (elution gradient: 10% to 30% petroleum ether solution of ethyl acetate) to give 2-chloro-3-cyclopropylpyridine as a colorless oil. Yield: 1 g (6 mmol, 60% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.20 (dd, J = 4.7, 1.8 Hz, 1H), 7.24-7.28 (m, 1H), 7.14 (br dd, J = 7.6, 4.8 Hz, 1H), 2.12-2.21 (m, 1H), 1.04-1.11 (m, 2H), 0.67 -0.72 (m, 2H).
References
[1] Patent: WO2014/207601, 2014, A1. Location in patent: Page/Page column 70; 72
2-chloro-3-cyclopropylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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