N-Cyano-N-phenyl-p-toluenesulfonaMide
- Product Name
- N-Cyano-N-phenyl-p-toluenesulfonaMide
- CAS No.
- 55305-43-6
- Chemical Name
- N-Cyano-N-phenyl-p-toluenesulfonaMide
- Synonyms
- N-Cyano-N-phenyl-p-toluenesulfomide;N-Cyano-4-methyl-N-phenylbenzenesulfonamide;N-CYANO-P-TOLUENESULFONANILIDE;N-Cyano-N-phenyl-p-toluenesulfonaMide;N-Cyano-N-phenyl-p-toluenesulphonamide;N-cyano-4-methyl-N-phenylbenzene-1-sulfonamide;Benzenesulfonamide, N-cyano-4-methyl-N-phenyl-
- CBNumber
- CB42643434
- Molecular Formula
- C14H12N2O2S
- Formula Weight
- 272.32
- MOL File
- 55305-43-6.mol
N-Cyano-N-phenyl-p-toluenesulfonaMide Property
- Melting point:
- 85-87 °C
- Boiling point:
- 418.4±38.0 °C(Predicted)
- Density
- 1.317±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- -8.96±0.50(Predicted)
- color
- White
- InChI
- InChI=1S/C14H12N2O2S/c1-12-7-9-14(10-8-12)19(17,18)16(11-15)13-5-3-2-4-6-13/h2-10H,1H3
- InChIKey
- CIIFNSIDKZSDBR-UHFFFAOYSA-N
- SMILES
- C1(S(N(C#N)C2=CC=CC=C2)(=O)=O)=CC=C(C)C=C1
Safety
- Safety Statements
- 24/25
- HS Code
- 29350090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C989428
- Product name
- N-Cyano-N-phenyl-p-toluenesulfonamide
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- JK1809267
- Product name
- N-Cyano-N-phenyl-p-toluenesulfonamide
- Packaging
- 1g
- Price
- $143
- Updated
- 2021/12/16
- Product number
- 8769-1-49
- Product name
- N-Cyano-N-phenyl-p-toluenesulfonamide
- Packaging
- 1g
- Price
- $208
- Updated
- 2021/12/16
- Product number
- JK1809267
- Product name
- N-Cyano-N-phenyl-p-toluenesulfonamide
- Packaging
- 5g
- Price
- $523
- Updated
- 2021/12/16
- Product number
- V6578
- Product name
- N-Cyano-N-phenyl-p-toluenesulfonamide
- Packaging
- 5g
- Price
- $608
- Updated
- 2021/12/16
N-Cyano-N-phenyl-p-toluenesulfonaMide Chemical Properties,Usage,Production
Uses
N-Cyano-N-phenyl-p-toluenesulfonamide is a useful research reactant for the synthesis of synthesis of 1,2,4-triazol-3-imines through stepwise cycloaddition.
Synthesis
64-10-8
98-59-9
55305-43-6
In a dry 250 mL Schlenk flask, phenylurea (10.9 g, 80 mmol) was dissolved in pyridine (54 mL). The flask was placed in a room temperature water bath and stirred. Tosyl chloride (52.8 g, 277 mmol) was added slowly over 5 minutes. The reaction mixture was continued to be stirred for 20 minutes and then slowly poured into ice-cooled water (400 mL) under mechanical stirring. The precipitate formed during mechanical stirring was filtered and washed with plenty of water. The crude product was treated with ethanol (50 mL) and recrystallized from the same solvent. The precipitate was purified by column chromatography using heptane: ethyl acetate (15:1) as eluent to afford N-cyano-4-methyl-N-phenylbenzenesulfonamide as a colorless solid (16.5 g, 76% yield).
References
[1] Angewandte Chemie - International Edition, 2011, vol. 50, # 2, p. 519 - 522
[2] Chemistry - A European Journal, 2011, vol. 17, # 15, p. 4217 - 4222
[3] Advanced Synthesis and Catalysis, 2015, vol. 357, # 16-17, p. 3419 - 3423
[4] Tetrahedron Letters, 2016, vol. 57, # 11, p. 1205 - 1209
[5] Organic Letters, 2016, vol. 18, # 5, p. 1100 - 1103
N-Cyano-N-phenyl-p-toluenesulfonaMide Preparation Products And Raw materials
Raw materials
Preparation Products
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