Methyl 4-aMino-3-(MethylaMino)benzoate
- Product Name
- Methyl 4-aMino-3-(MethylaMino)benzoate
- CAS No.
- 616224-38-5
- Chemical Name
- Methyl 4-aMino-3-(MethylaMino)benzoate
- Synonyms
- Methyl 4-aMino-3-(MethylaMino)benzoate;Methyl 4-amino-3-(methylamino)benzoate - [M71835];Benzoic acid, 4-amino-3-(methylamino)-, methyl ester
- CBNumber
- CB42651822
- Molecular Formula
- C9H12N2O2
- Formula Weight
- 180.2
- MOL File
- 616224-38-5.mol
Methyl 4-aMino-3-(MethylaMino)benzoate Property
- Boiling point:
- 369.9±32.0 °C(Predicted)
- Density
- 1.208±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.42±0.10(Predicted)
- Appearance
- Gray to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M328598
- Product name
- Methyl4-amino-3-(methylamino)benzoate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M328598
- Product name
- Methyl4-amino-3-(methylamino)benzoate
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- M328598
- Product name
- Methyl4-amino-3-(methylamino)benzoate
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- V6914
- Product name
- Methyl4-amino-3-(methylamino)benzoate
- Packaging
- 1g
- Price
- $211
- Updated
- 2021/12/16
- Product number
- CHM0393146
- Product name
- METHYL-4-AMINO-3-(METHYLAMINO)BENZOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.75
- Updated
- 2021/12/16
Methyl 4-aMino-3-(MethylaMino)benzoate Chemical Properties,Usage,Production
Synthesis
251643-13-7
616224-38-5
General procedure for the synthesis of methyl 4-amino-3-(methylamino)benzoate from methyl 3-(methylamino)-4-nitrobenzoate: at 0 °C, an aqueous sodium bisulfite solution (17.4 g, 100 mmol, dissolved in 80 mL of water) was slowly added to methyl-3-(methylamino)-4-nitrobenzoate (855 mg, 4.75 mmol) containing a tetrahydrofuran (70 mL) and ethanol (30 mL) in a mixed solution. The reaction solution was transformed from an orange solution to an orange suspension. The reaction mixture was stirred at room temperature for 2 hours, during which time the color of the suspension gradually changed from orange to yellow. Subsequently, saturated sodium bicarbonate solution (100 mL) was added, at which point the suspension further changed to colorless. The reaction mixture was extracted with ethyl acetate (2 x 100 mL). The organic phases were combined, washed with brine (30 mL) and dried over anhydrous magnesium sulfate. After filtration, the organic phase was concentrated and dried under high vacuum to afford methyl 4-amino-3-(methylamino)benzoate (586 mg, 68% yield) as a yellow oily product. After standing for 10 min, the oily material started to crystallize. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 2.89 (s, 3H), 3.37-3.81 (m, 2H), 3.85 (s, 3H), 6.67 (d, J = 8.01 Hz, 1H), 7.33 (d, J = 1.37 Hz, 1H), 7.44 (dd, J = 8.11,1.66 Hz, 1H).
References
[1] Patent: WO2005/80388, 2005, A1. Location in patent: Page/Page column 89
[2] Patent: US2018/170908, 2018, A1. Location in patent: Paragraph 0416
[3] Patent: US2011/130398, 2011, A1. Location in patent: Page/Page column 72
[4] Patent: US2011/111046, 2011, A1. Location in patent: Page/Page column 18
[5] Patent: WO2011/58473, 2011, A1. Location in patent: Page/Page column 38; 39
Methyl 4-aMino-3-(MethylaMino)benzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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