1-(4-BroMo-2,6-difluoro-phenyl)-ethanone
- Product Name
- 1-(4-BroMo-2,6-difluoro-phenyl)-ethanone
- CAS No.
- 746630-34-2
- Chemical Name
- 1-(4-BroMo-2,6-difluoro-phenyl)-ethanone
- Synonyms
- 2,6-Difluoro-4-bromophenone;4’-Bromo-2’,6’-difluoroacetophenone;4'-bromo-2',6'-difluoroacetophenone;(2E)-3-(5-methyl-49-furyl)acrylic acid;4'-Bromo-2',6'-difluoroacetophenone 97%;1-(4-BroMo-2,6-difluoro-phenyl)-ethanone;Ethanone, 1-(4-bromo-2,6-difluorophenyl)-
- CBNumber
- CB42652319
- Molecular Formula
- C8H5BrF2O
- Formula Weight
- 235.03
- MOL File
- 746630-34-2.mol
1-(4-BroMo-2,6-difluoro-phenyl)-ethanone Property
- Boiling point:
- 246.1±40.0 °C(Predicted)
- Density
- 1.614±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- liquid
- color
- Clear, almost colourless to faint lemon
Safety
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B701070
- Product name
- 1-(4-Bromo-2,6-difluorophenyl)ethanone
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- PC32806
- Product name
- 4'-Bromo-2',6'-difluoroacetophenone
- Purity
- 97%
- Packaging
- 250mg
- Price
- $28
- Updated
- 2021/12/16
- Product number
- 2617-B-62
- Product name
- 4'-Bromo-2',6'-difluoroacetophenone
- Packaging
- 250mg
- Price
- $31
- Updated
- 2021/12/16
- Product number
- PC32806
- Product name
- 4'-Bromo-2',6'-difluoroacetophenone
- Purity
- 97%
- Packaging
- 1g
- Price
- $69
- Updated
- 2021/12/16
- Product number
- 2617-B-62
- Product name
- 4'-Bromo-2',6'-difluoroacetophenone
- Packaging
- 1g
- Price
- $76
- Updated
- 2021/12/16
1-(4-BroMo-2,6-difluoro-phenyl)-ethanone Chemical Properties,Usage,Production
Synthesis
184910-20-1
75-36-5
746630-34-2
1. Anhydrous aluminum trichloride (AlCl3, 16.89 g, 126.7 mmol) was dissolved in dichloromethane (DCM, 130 mL) and acetyl chloride (AcCl, 9 mL, 126.7 mmol) was added slowly at 0 °C. 2. The reaction mixture was stirred at 0 °C for 1 hour. 3. In another vessel, (4-bromo-2,6-difluorophenyl)trimethylsilane (27.48 g, 105.59 mmol) was dissolved in dichloromethane (DCM, 70 mL). 4. The solution from Step 3 was slowly added to the reaction mixture from Step 2 at -80 °C. 5. The reaction mixture was stirred at -80 °C for 16 hours. 6. Upon completion of the reaction, the reaction was quenched with aqueous ammonium chloride at 0 °C and extracted with ether (Et2O). 7. The organic layers were combined and dried with anhydrous magnesium sulfate. 8. The crude product was purified by column chromatography (eluent: ethyl acetate/hexane = 1/10) to afford 1-(4-bromo-2,6-difluorophenyl)ethanone (19.89 g, 74% yield). 9. The structure of the product was investigated by 1H-1H-1 , 1H-2,6-difluorophenylacetonitrile. 9. The structure of the product was confirmed by 1H-NMR (CDCl3, δ): 7.16 (2H, m), 2.58 (3H, s).
References
[1] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0140
1-(4-BroMo-2,6-difluoro-phenyl)-ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
1-(4-BroMo-2,6-difluoro-phenyl)-ethanone Suppliers
- Tel
- 025-83697070 13913916777
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16059
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9520
- Advantage
- 58
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- +86-18068513926
- Fax
- 0086-519-85153711
- Country
- China
- ProdList
- 1277
- Advantage
- 55
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9899
- Advantage
- 55
- Tel
- 400-400-164-7117 18317119277
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39999
- Advantage
- 60
- Tel
- 20-66003216 18666003216
- Fax
- +86-20-28069063
- info@porsefinechemical.com
- Country
- China
- ProdList
- 1941
- Advantage
- 62
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9478
- Advantage
- 58
- Tel
- 13764359345
- Fax
- 021-51632502
- 990877971@qq.com
- Country
- China
- ProdList
- 1735
- Advantage
- 50