ChemicalBook > CAS DataBase List > KML-29

KML-29

Product Name: KML-29
CAS No.: 1380424-42-9
Chemical Name: KML-29
Synonyms: KML-29;CS-2396;KML29 (KML-29);KML29;KML-29;KML 29;KML29, 10 mM in DMSO;LPS,allodynia,Monoacylglycerol lipase,KML29,MAGL,inhibit,2-AG,Inhibitor,HFIP,KML 29,KML-29;1,1,1,3,3,3-hexafluoropropan-2-yl 4-[bis(2H-1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-carboxylate;1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate;4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester;1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
CBNumber: CB42653891
Molecular Formula: C24H21F6NO7
Formula Weight: 549.42
MOL File: 1380424-42-9.mol

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KML-29 Property

Melting point:: 204-206°C
Boiling point:: 554.8±50.0 °C(Predicted)
Density: 1.511±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly, Heated)
pka: 13.32±0.29(Predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2166
Product name: KML29
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $53.75
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2166
Product name: KML29
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $230
Updated: 2025/07/31

Cayman Chemical

Product number: 11777
Product name: KML29
Purity: ≥98%
Packaging: 5mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 11777
Product name: KML29
Purity: ≥98%
Packaging: 10mg
Price: $112
Updated: 2024/03/01

Cayman Chemical

Product number: 11777
Product name: KML29
Purity: ≥98%
Packaging: 50mg
Price: $468
Updated: 2024/03/01

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KML-29 Chemical Properties,Usage,Production

Description

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. KML29 is an O-hexafluoroisopropyl carbamate analog of JZL 184 that potently and selectively inhibits MAGL (IC₅₀s = 15, 43, and 5.9 nM in mouse, rat, and human brain proteomes, respectively) over FAAH (IC₅₀s >50 μM). At 5-20 mg/kg, KML29 dose-dependently blocks mouse brain MAGL activity in vivo, without any measurable effect on FAAH activity. As a second generation MAGL inhibitor, KML29 supersedes the low-level cross reactivity that JZL 184 displays for FAAH yet still maintains comparable potency to its parent compound.

Uses

KML-29 is an extremely specific monoacylglycerol lipase (MAGL) inhibitor. KML-2 should be useful to distinguish between actions of 2-arachidonoyl glycerol (an endogenous ligand of cannabinoid receptors that is deactivated by MAGL) and anandamide, another endocannabinoid.

in vivo

KML29 enhibits antinociceptive activity without cannabimimetic side effects^[3].
KML29 (20 mg/kg) has a significant but modest protective effect against LPS-induced fever^[3].

Animal Model:	C57Bl/6 mice^[2].
Dosage:	1-40 mg/kg.
Administration:	P.O. single dose.
Result:	Selectively inhibited MAGL in mice.

Animal Model:	Wistar albino male rats^[2].
Dosage:	20 mg/kg (+LPS E. coli O111:B4 (250 μg/kg, sc)).
Administration:	SC.
Result:	Administration of KML29 simultaneously with LPS E. coli O111:B4 significantly decreased ?T (with 5% type 1 error, 1.7 fold) compared to saline+LPS E. coli O111:B4. Administration of KML29 simultaneously with LPS E. coli O111:B4 resulted in decreased plateau phase of fever compared to LPS E. E. coli O111:B4+saline administration.

storage

Store at -20°C

References

[1] JAE WON CHANG. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates.[J]. Chemistry & biology, 2012: 579-588. DOI: 10.1016/j.chembiol.2012.03.009

KML-29 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from KML-29 manufacturers

Career Henan Chemical Co

Product: KML-29 1380424-42-9
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g； 1kg; 25kg
Release date: 2020-01-10

1380424-42-9, KML-29Related Search:

KML-29

KML29;KML-29;KML 29

4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester

CS-2396

KML29 (KML-29)

1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester

1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate

LPS,allodynia,Monoacylglycerol lipase,KML29,MAGL,inhibit,2-AG,Inhibitor,HFIP,KML 29,KML-29

1,1,1,3,3,3-hexafluoropropan-2-yl 4-[bis(2H-1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-carboxylate

KML29, 10 mM in DMSO

1380424-42-9

C24H21F6NO7

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals